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    vegfaa vascular endothelial growth factor Aa [ Danio rerio (zebrafish) ]

    Gene ID: 30682, updated on 21-Jul-2019

    Summary

    Official Symbol
    vegfaaprovided by ZNC
    Official Full Name
    vascular endothelial growth factor Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-273
    See related
    Ensembl:ENSDARG00000103542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    vegf; vegfa; wu:fj82c06

    Genomic context

    See vegfaa in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4287539..4317955, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (4459314..4488660, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 16 NC_007127.5 (4641621..4671204)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 15 homolog Neighboring gene uncharacterized LOC101886145 Neighboring gene tetratricopeptide repeat domain 29 Neighboring gene protein phosphatase 1, regulatory subunit 8b

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vascular endothelial growth factor receptor 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angioblast cell migration from lateral mesoderm to midline IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardioblast migration to the midline involved in heart rudiment formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial progenitor cell migration to the midline involved in heart field formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of angioblast cell migration involved in selective angioblast sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    venous blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vascular endothelial growth factor A-A
    Names
    VEGF-A-A
    etID309976.16
    vascular endothelial growth factor A
    vegf-a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110349.2NP_001103819.2  vascular endothelial growth factor A-A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001103819.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is lacking an in-frame, coding exon compared to transcript variant 1, resulting in a shorter isoform (2) that is missing a 44 aa segment, compared to isoform 1.
      Source sequence(s)
      AF059661
      UniProtKB/Swiss-Prot
      O73682
      Conserved Domains (1) summary
      smart00141
      Location:47129
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    2. NM_131408.3NP_571483.1  vascular endothelial growth factor A-A isoform 1 precursor

      See identical proteins and their annotated locations for NP_571483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF016244
      UniProtKB/Swiss-Prot
      O73682
      Related
      ENSDARP00000133415.1, ENSDART00000167719.2
      Conserved Domains (2) summary
      smart00141
      Location:47129
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:136188
      VEGF_C; VEGF heparin-binding domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      4287539..4317955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292018.3XP_009290293.1  vascular endothelial growth factor A-A isoform X1

      Conserved Domains (1) summary
      pfam00341
      Location:49127
      PDGF; PDGF/VEGF domain

    RNA

    1. XR_002455712.1 RNA Sequence

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