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    Dapk1 death associated protein kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306722, updated on 2-Oct-2018

    Summary

    Official Symbol
    Dapk1provided by RGD
    Official Full Name
    death associated protein kinase 1provided by RGD
    Primary source
    RGD:1311629
    See related
    Ensembl:ENSRNOG00000018198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Lung (RPKM 135.2), Kidney (RPKM 87.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Dapk1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4297038..4454941, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (6525247..6683920, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene similar to Cathepsin L precursor (Major excreted protein) (MEP) Neighboring gene cathepsin L-like 3 Neighboring gene uncharacterized LOC102552469 Neighboring gene uncharacterized LOC100912124

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of NMDA receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    death-associated protein kinase 1
    NP_001100805.2
    XP_006253584.1
    XP_006253585.1
    XP_008769662.1
    XP_008769663.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107335.2NP_001100805.2  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001100805.2

      Status: VALIDATED

      Source sequence(s)
      AABR07026909, AABR07026910, AABR07026911
      UniProtKB/TrEMBL
      F1LNN8
      Related
      ENSRNOP00000062122.1, ENSRNOT00000066950.2
      Conserved Domains (6) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:439564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449541
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      4297038..4454941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771441.2XP_008769663.1  death-associated protein kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_008769663.1

      UniProtKB/TrEMBL
      A0A0G2K5V8
      Conserved Domains (6) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:439564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449541
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
    2. XM_008771440.2XP_008769662.1  death-associated protein kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_008769662.1

      UniProtKB/TrEMBL
      A0A0G2K5V8
      Conserved Domains (6) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:439564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449541
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
    3. XM_006253522.3XP_006253584.1  death-associated protein kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253584.1

      UniProtKB/TrEMBL
      A0A0G2K5V8
      Related
      ENSRNOP00000073577.1, ENSRNOT00000080750.1
      Conserved Domains (6) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:439564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449541
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]
    4. XM_006253523.3XP_006253585.1  death-associated protein kinase 1 isoform X2

      See identical proteins and their annotated locations for XP_006253585.1

      UniProtKB/TrEMBL
      F1LNN8
      Conserved Domains (6) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:439564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08782
      Location:13081393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449541
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:412442
      ANK; ANK repeat [structural motif]

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      4059212..4219046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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