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    Cd34 CD34 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305081, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cd34provided by RGD
    Official Full Name
    CD34 moleculeprovided by RGD
    Primary source
    RGD:1306863
    See related
    Ensembl:ENSRNOG00000045558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 753.0), Lung (RPKM 440.7) and 7 other tissues See more
    Orthologs

    Genomic context

    See Cd34 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (113691842..113711259)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (118531837..118551216)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352602 Neighboring gene plexin A2 Neighboring gene uncharacterized LOC108352603 Neighboring gene uncharacterized LOC102550245 Neighboring gene uncharacterized LOC102550527 Neighboring gene microRNA 29b-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sulfate binding IEA
    Inferred from Electronic Annotation
    more info
     
    sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endothelium development ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerular endothelium development IEA
    Inferred from Electronic Annotation
    more info
     
    glomerular endothelium development ISO
    Inferred from Sequence Orthology
    more info
     
    glomerular filtration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    mesangial cell-matrix adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric glomerular mesangial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric glomerular mesangial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood coagulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-2 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-2 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    paracrine signaling ISO
    Inferred from Sequence Orthology
    more info
     
    paracrine signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glial cell-derived neurotrophic factor secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glial cell-derived neurotrophic factor secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of granulocyte colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of granulocyte colony-stimulating factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of odontogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    tissue homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transdifferentiation IEA
    Inferred from Electronic Annotation
    more info
     
    transdifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    vascular wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    glomerular endothelium fenestra IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    intercellular bridge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hematopoietic progenitor cell antigen CD34
    Names
    CD34 antigen

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107202.2NP_001100672.1  hematopoietic progenitor cell antigen CD34 precursor

      See identical proteins and their annotated locations for NP_001100672.1

      Status: PROVISIONAL

      Source sequence(s)
      EU448292
      UniProtKB/TrEMBL
      B1PLB1
      Related
      ENSRNOP00000074896.1, ENSRNOT00000084709.1
      Conserved Domains (1) summary
      pfam06365
      Location:191385
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      113691842..113711259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769857.2XP_008768079.1  hematopoietic progenitor cell antigen CD34 isoform X1

      See identical proteins and their annotated locations for XP_008768079.1

      UniProtKB/TrEMBL
      B1PLB2
      Related
      ENSRNOP00000053987.3, ENSRNOT00000057160.3
      Conserved Domains (1) summary
      pfam06365
      Location:191329
      CD34_antigen; CD34/Podocalyxin family

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      105904553..105923681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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