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    Gbp1 guanylate binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304266, updated on 19-Apr-2019

    Summary

    Official Symbol
    Gbp1provided by RGD
    Official Full Name
    guanylate binding protein 1provided by RGD
    Primary source
    RGD:1311877
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 418.1) and Muscle (RPKM 28.7) See more

    Genomic context

    See Gbp1 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248343334..248423402)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (266908013..266948528)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 4 Neighboring gene guanylate binding protein 2 Neighboring gene guanylate-binding protein 6-like Neighboring gene guanylate binding protein 3 Neighboring gene similar to guanylate binding protein 1, interferon-inducible, 67kDa

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GMP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytokine binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of interleukin-2 secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein localization to vacuole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    symbiont-containing vacuole membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-induced guanylate-binding protein 1; guanylate-binding protein 1
    Names
    guanylate binding protein 1, interferon-inducible, 67kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      248343334..248423402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591353.1XP_017446842.1  guanylate-binding protein 1

      Conserved Domains (4) summary
      TIGR02473
      Location:542673
      flagell_FliJ; flagellar export protein FliJ
      pfam02841
      Location:285581
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:20283
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:291581
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. XM_008761538.1XP_008759760.1  guanylate-binding protein 1

      See identical proteins and their annotated locations for XP_008759760.1

      Conserved Domains (4) summary
      TIGR02473
      Location:542673
      flagell_FliJ; flagellar export protein FliJ
      pfam02841
      Location:285581
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:20283
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:291581
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. XM_006233425.3XP_006233487.1  guanylate-binding protein 1

      See identical proteins and their annotated locations for XP_006233487.1

      Conserved Domains (4) summary
      TIGR02473
      Location:542673
      flagell_FliJ; flagellar export protein FliJ
      pfam02841
      Location:285581
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:20283
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:291581
      GBP_C; Guanylate-binding protein, C-terminal domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      223441822..223476423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006224278.2XP_006224340.1  guanylate-binding protein 1

      Conserved Domains (4) summary
      TIGR02473
      Location:542673
      flagell_FliJ; flagellar export protein FliJ
      pfam02841
      Location:285581
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:20283
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:291581
      GBP_C; Guanylate-binding protein, C-terminal domain
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