Format

Send to:

Choose Destination
    • Showing Current items.

    Usp25 ubiquitin specific peptidase 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304150, updated on 10-Oct-2019

    Summary

    Official Symbol
    Usp25provided by RGD
    Official Full Name
    ubiquitin specific peptidase 25provided by RGD
    Primary source
    RGD:1309003
    See related
    Ensembl:ENSRNOG00000001573
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Muscle (RPKM 349.5), Spleen (RPKM 266.8) and 9 other tissues See more

    Genomic context

    See Usp25 in Genome Data Viewer
    Location:
    11p11-q11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (15436080..15558646)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (18721858..18745175) , (19095215..19215613)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693506 Neighboring gene uncharacterized LOC102548078 Neighboring gene microRNA let-7c-1 Neighboring gene microRNA 99a

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 25
    Names
    ubiquitin specific protease 25
    NP_001100584.1
    XP_006248060.1
    XP_006248061.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107114.1NP_001100584.1  ubiquitin carboxyl-terminal hydrolase 25

      See identical proteins and their annotated locations for NP_001100584.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473989
      UniProtKB/TrEMBL
      D4ACD3
      Related
      ENSRNOP00000002150.4, ENSRNOT00000002150.6
      Conserved Domains (3) summary
      cd02665
      Location:171656
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:1560
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      pfam00443
      Location:169406
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      15436080..15558646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247999.3XP_006248061.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

      Conserved Domains (3) summary
      cd02665
      Location:171656
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:1560
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      pfam00443
      Location:169406
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_006247998.3XP_006248060.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X1

      Conserved Domains (1) summary
      cd02665
      Location:37434
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      15609163..15716459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center