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    ANXA1 annexin A1 [ Homo sapiens (human) ]

    Gene ID: 301, updated on 12-Aug-2018

    Summary

    Official Symbol
    ANXA1provided by HGNC
    Official Full Name
    annexin A1provided by HGNC
    Primary source
    HGNC:HGNC:533
    See related
    Ensembl:ENSG00000135046 MIM:151690; Vega:OTTHUMG00000020016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANX1; LPC1
    Summary
    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in esophagus (RPKM 2850.3), bone marrow (RPKM 574.5) and 4 other tissues See more
    Orthologs

    Genomic context

    See ANXA1 in Genome Data Viewer
    Location:
    9q21.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (73151731..73170393)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (75766721..75785309)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 1 subfamily D member 1, pseudogene Neighboring gene uncharacterized LOC105376081 Neighboring gene uncharacterized LOC105376082 Neighboring gene uncharacterized LOC101927281

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystem (from REACTOME)
      Formyl peptide receptors bind formyl peptides and many other ligands, organism-specific biosystemThe formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF)....
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ18726

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA/DNA annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA/DNA annealing activity IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding involved in cell-cell adhesion HDA PubMed 
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded DNA-dependent ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase A2 inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipase A2 inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding, bridging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    CONTRIBUTES_TO single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    CONTRIBUTES_TO single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton reorganization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-beta T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    arachidonic acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to vascular endothelial growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    endocrine pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    NOT estrous cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    gliogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gliogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    granulocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    granulocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hepatocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myoblast migration involved in skeletal muscle regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myoblast migration involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T-helper 2 cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-8 secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of interleukin-8 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neutrophil clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T-helper 1 cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T-helper 1 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-2 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neutrophil apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of neutrophil apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prolactin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prolactin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    prostate gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interleukin-1 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of interleukin-1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of leukocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to estradiol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction HDA PubMed 
    cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extrinsic component of external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion HDA PubMed 
    lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle HDA PubMed 

    General protein information

    Preferred Names
    annexin A1
    Names
    annexin I (lipocortin I)
    annexin-1
    calpactin II
    calpactin-2
    chromobindin-9
    phospholipase A2 inhibitory protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000700.2NP_000691.1  annexin A1

      See identical proteins and their annotated locations for NP_000691.1

      Status: REVIEWED

      Source sequence(s)
      AA039737, AL359997, CX870105, X05908
      Consensus CDS
      CCDS6645.1
      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Related
      ENSP00000257497.6, OTTHUMP00000021474, ENST00000257497.10, OTTHUMT00000052664
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      73151731..73170393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014657.1XP_016870146.1  annexin A1 isoform X1

      Conserved Domains (1) summary
      pfam00191
      Location:129194
      Annexin; Annexin
    2. XM_011518609.1XP_011516911.1  annexin A1 isoform X2

      See identical proteins and their annotated locations for XP_011516911.1

      UniProtKB/Swiss-Prot
      P04083
      UniProtKB/TrEMBL
      Q5TZZ9
      Related
      ENSP00000366109.1, OTTHUMP00000021475, ENST00000376911.1, OTTHUMT00000052665
      Conserved Domains (1) summary
      pfam00191
      Location:118183
      Annexin; Annexin
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