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    DPP7 dipeptidyl peptidase 7 [ Homo sapiens (human) ]

    Gene ID: 29952, updated on 8-Jul-2021

    Summary

    Official Symbol
    DPP7provided by HGNC
    Official Full Name
    dipeptidyl peptidase 7provided by HGNC
    Primary source
    HGNC:HGNC:14892
    See related
    Ensembl:ENSG00000176978 MIM:610537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QPP; DPP2; DPPII
    Summary
    The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 29.2), testis (RPKM 27.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DPP7 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137110540..137117980, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140004998..140009185, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAN1B1 divergent transcript Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene uncharacterized LOC105376328 Neighboring gene microRNA 3621 Neighboring gene leucine rich repeat containing 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dipeptidyl peptidase 2
    Names
    DPP II
    carboxytripeptidase
    dipeptidyl aminopeptidase II
    dipeptidyl arylamidase II
    dipeptidyl-peptidase II
    quiescent cell proline dipeptidase
    NP_037511.2
    XP_005266132.1
    XP_006717146.1
    XP_011516901.1
    XP_011516902.1
    XP_016870140.1
    XP_016870141.1
    XP_024303293.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013379.3NP_037511.2  dipeptidyl peptidase 2 preproprotein

      See identical proteins and their annotated locations for NP_037511.2

      Status: REVIEWED

      Source sequence(s)
      AF154502, AL533195, BC016961, BX400716
      Consensus CDS
      CCDS7030.1
      UniProtKB/Swiss-Prot
      Q9UHL4
      Related
      ENSP00000360635.2, ENST00000371579.7
      Conserved Domains (1) summary
      cl21494
      Location:38465
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      137110540..137117980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518600.1XP_011516902.1  dipeptidyl peptidase 2 isoform X4

      Conserved Domains (1) summary
      cl21494
      Location:56457
      Abhydrolase; alpha/beta hydrolases
    2. XM_017014651.1XP_016870140.1  dipeptidyl peptidase 2 isoform X5

    3. XM_011518599.2XP_011516901.1  dipeptidyl peptidase 2 isoform X2

      Conserved Domains (1) summary
      cl21494
      Location:86487
      Abhydrolase; alpha/beta hydrolases
    4. XM_024447525.1XP_024303293.1  dipeptidyl peptidase 2 isoform X7

      Conserved Domains (1) summary
      cl21494
      Location:166319
      Abhydrolase; alpha/beta hydrolases
    5. XM_017014652.2XP_016870141.1  dipeptidyl peptidase 2 isoform X6

    6. XM_006717083.4XP_006717146.1  dipeptidyl peptidase 2 isoform X3

      Conserved Domains (1) summary
      cl21494
      Location:38449
      Abhydrolase; alpha/beta hydrolases
    7. XM_005266075.4XP_005266132.1  dipeptidyl peptidase 2 isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:38538
      Abhydrolase; alpha/beta hydrolases
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