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    HOOK2 hook microtubule tethering protein 2 [ Homo sapiens (human) ]

    Gene ID: 29911, updated on 12-May-2019

    Summary

    Official Symbol
    HOOK2provided by HGNC
    Official Full Name
    hook microtubule tethering protein 2provided by HGNC
    Primary source
    HGNC:HGNC:19885
    See related
    Ensembl:ENSG00000095066 MIM:607824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HK2
    Summary
    Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
    Expression
    Ubiquitous expression in fat (RPKM 18.1), duodenum (RPKM 14.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See HOOK2 in Genome Data Viewer
    Location:
    19p13.13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (12763002..12778484, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12873817..12889248, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) Neighboring gene bestrophin 2 Neighboring gene microRNA 5684 Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ26218

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    FHF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with HOPS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein Hook homolog 2
    Names
    h-hook2
    hHK2
    hook homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100176.1NP_001093646.1  protein Hook homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001093646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AF044924, BC012443, DB474423
      Consensus CDS
      CCDS42507.1
      UniProtKB/Swiss-Prot
      Q96ED9
      Related
      ENSP00000264827.4, ENST00000264827.9
      Conserved Domains (1) summary
      pfam05622
      Location:8704
      HOOK; HOOK protein
    2. NM_013312.2NP_037444.2  protein Hook homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_037444.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF044924, BC012443, DB474423
      Consensus CDS
      CCDS42508.1
      UniProtKB/Swiss-Prot
      Q96ED9
      Related
      ENSP00000380785.2, ENST00000397668.7
      Conserved Domains (1) summary
      pfam05622
      Location:8706
      HOOK; HOOK protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      12763002..12778484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527945.2XP_011526247.1  protein Hook homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_011526247.1

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    2. XM_017026721.1XP_016882210.1  protein Hook homolog 2 isoform X4

    3. XM_005259876.4XP_005259933.1  protein Hook homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_005259933.1

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    4. XM_005259877.4XP_005259934.1  protein Hook homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_005259934.1

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    5. XM_011527944.2XP_011526246.1  protein Hook homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_011526246.1

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    6. XM_005259874.2XP_005259931.1  protein Hook homolog 2 isoform X2

      Conserved Domains (1) summary
      pfam05622
      Location:8703
      HOOK; HOOK protein
    7. XM_005259873.2XP_005259930.1  protein Hook homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam05622
      Location:8705
      HOOK; HOOK protein
    8. XM_011527943.2XP_011526245.1  protein Hook homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_011526245.1

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    9. XM_017026720.1XP_016882209.1  protein Hook homolog 2 isoform X3

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    10. XM_011527946.2XP_011526248.1  protein Hook homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_011526248.1

      Conserved Domains (1) summary
      pfam05622
      Location:1633
      HOOK; HOOK protein
    11. XM_011527947.2XP_011526249.1  protein Hook homolog 2 isoform X5

      Conserved Domains (1) summary
      pfam05622
      Location:1571
      HOOK; HOOK protein
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