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    GTF3C1 general transcription factor IIIC subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2975, updated on 7-Oct-2018

    Summary

    Official Symbol
    GTF3C1provided by HGNC
    Official Full Name
    general transcription factor IIIC subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4664
    See related
    Ensembl:ENSG00000077235 MIM:603246; Vega:OTTHUMG00000176805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TFIIIC; TFIIIC220; TFIIICalpha
    Expression
    Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See GTF3C1 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (27460613..27549930, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561251, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 4 receptor Neighboring gene interleukin 21 receptor Neighboring gene IL21R antisense RNA 1 Neighboring gene KIAA0556 Neighboring gene uncharacterized LOC107984874 Neighboring gene uncharacterized LOC100128079

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686A111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IC
    Inferred by Curator
    more info
    PubMed 
    contributes_to RNA polymerase III general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane HDA PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    general transcription factor 3C polypeptide 1
    Names
    TF3C-alpha
    TFIIIC 220 kDa subunit
    TFIIIC box B-binding subunit
    general transcription factor IIIC, polypeptide 1 (alpha subunit)
    general transcription factor IIIC, polypeptide 1, alpha 220kDa
    transcription factor IIIC 220 kDa subunit
    transcription factor IIIC subunit alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286242.1NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC002303, AC025275, BC044857, BC137229
      Consensus CDS
      CCDS66988.1
      UniProtKB/Swiss-Prot
      Q12789
      Related
      ENSP00000455417.1, OTTHUMP00000255146, ENST00000561623.5, OTTHUMT00000433855
      Conserved Domains (1) summary
      pfam04182
      Location:174250
      B-block_TFIIIC; B-block binding subunit of TFIIIC
    2. NM_001520.3NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

      See identical proteins and their annotated locations for NP_001511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC044857, BC137229, BP283960, CA414192, U02619
      Consensus CDS
      CCDS32414.1
      UniProtKB/Swiss-Prot
      Q12789
      Related
      ENSP00000348510.4, OTTHUMP00000255147, ENST00000356183.8, OTTHUMT00000433856
      Conserved Domains (2) summary
      pfam04182
      Location:174250
      B-block_TFIIIC; B-block binding subunit of TFIIIC
      cl22974
      Location:18811975
      HpaP; Type III secretion protein (HpaP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      27460613..27549930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023188.2XP_016878677.1  general transcription factor 3C polypeptide 1 isoform X1

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