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    C1qbp complement C1q binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29681, updated on 10-Oct-2019

    Summary

    Official Symbol
    C1qbpprovided by RGD
    Official Full Name
    complement C1q binding proteinprovided by RGD
    Primary source
    RGD:2230
    See related
    Ensembl:ENSRNOG00000006949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Habp1; gC1qR
    Summary
    binds to the globular heads of complement component C1q [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 241.6), Adrenal (RPKM 231.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See C1qbp in Genome Data Viewer
    Location:
    10q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57613876..57618527, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (57359088..57363739, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352101 Neighboring gene nucleoporin 88 Neighboring gene RPA interacting protein Neighboring gene DEAH-box helicase 33 Neighboring gene derlin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91723

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    adrenergic receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement component C1q binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    complement component C1q binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement component C1q binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hyaluronic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    kininogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kininogen binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kininogen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mature ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mature ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mature ribosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of MDA-5 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of RIG-I signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of interferon-gamma production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dendritic cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of dendritic cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of trophoblast cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of complement activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic active zone EXP
    Inferred from Experiment
    more info
    PubMed 
    presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    complement component 1 Q subcomponent-binding protein, mitochondrial
    Names
    GC1q-R protein
    complement component 1, q subcomponent binding protein
    glycoprotein gC1qBP

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019259.2NP_062132.2  complement component 1 Q subcomponent-binding protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_062132.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070510
      UniProtKB/Swiss-Prot
      O35796
      Related
      ENSRNOP00000031020.3, ENSRNOT00000037517.5
      Conserved Domains (1) summary
      pfam02330
      Location:87270
      MAM33; Mitochondrial glycoprotein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      57613876..57618527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      54845644..54850295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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