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    Ltbp4 latent transforming growth factor beta binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292734, updated on 12-Aug-2018

    Summary

    Official Symbol
    Ltbp4provided by RGD
    Official Full Name
    latent transforming growth factor beta binding protein 4provided by RGD
    Primary source
    RGD:1307033
    See related
    Ensembl:ENSRNOG00000020871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 290.0), Lung (RPKM 259.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ltbp4 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (84118046..84152095, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (85328915..85361198, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L14-like Neighboring gene NUMB-like, endocytic adaptor protein Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene Sh3kbp1 binding protein 1 Neighboring gene spectrin, beta, non-erythrocytic 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    latent-transforming growth factor beta-binding protein 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170336.1NP_001163807.1  latent-transforming growth factor beta-binding protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC123095
      UniProtKB/TrEMBL
      D4A917
      Related
      ENSRNOP00000028322.4, ENSRNOT00000028322.6
      Conserved Domains (5) summary
      smart00179
      Location:885921
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:842874
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:418453
      TB; TB domain
      pfam07645
      Location:760800
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:575598
      cEGF; Complement Clr-like EGF-like

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      84118046..84152095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588897.1XP_017444386.1  latent-transforming growth factor beta-binding protein 4 isoform X2

    2. XM_008759116.2XP_008757338.1  latent-transforming growth factor beta-binding protein 4 isoform X1

      Conserved Domains (5) summary
      smart00179
      Location:854890
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:811843
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:387422
      TB; TB domain
      pfam07645
      Location:729769
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:544567
      cEGF; Complement Clr-like EGF-like
    3. XM_006228570.3XP_006228632.1  latent-transforming growth factor beta-binding protein 4 isoform X3

      Related
      ENSRNOP00000073336.1, ENSRNOT00000081796.1
      Conserved Domains (5) summary
      smart00179
      Location:818854
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:775807
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:351386
      TB; TB domain
      pfam07645
      Location:693733
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:508531
      cEGF; Complement Clr-like EGF-like

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      77011604..77043761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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