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    Fbln5 fibulin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29158, updated on 12-Aug-2018

    Summary

    Official Symbol
    Fbln5provided by RGD
    Official Full Name
    fibulin 5provided by RGD
    Primary source
    RGD:2594
    See related
    Ensembl:ENSRNOG00000050539
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may play a role in vascular growth and maturation during development and in lesions of injured vessels [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 322.4), Spleen (RPKM 270.0) and 6 other tissues See more
    Orthologs

    Genomic context

    See Fbln5 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125644797..125723957, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (134856694..134935853, complement)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene ovarian cancer G-protein coupled receptor 1-like Neighboring gene tandem C2 domains, nuclear Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene putative 60S ribosomal protein L37a-like Neighboring gene ataxin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    elastic fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    secretion IEA
    Inferred from Electronic Annotation
    more info
     
    secretion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    elastic fiber IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with elastic fiber ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibulin-5
    Names
    EVEC
    FIBL-5
    dance
    developmental arteries and neural crest EGF-like protein
    embryonic vascular EGF repeat-containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019153.3NP_062026.2  fibulin-5 precursor

      See identical proteins and their annotated locations for NP_062026.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078845
      UniProtKB/Swiss-Prot
      Q9WVH8
      Related
      ENSRNOP00000007004.5, ENSRNOT00000007004.7
      Conserved Domains (4) summary
      smart00179
      Location:207245
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:187210
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:258286
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:121165
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      125644797..125723957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240459.3XP_006240521.1  fibulin-5 isoform X1

      Conserved Domains (4) summary
      smart00179
      Location:220258
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:200223
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:271299
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:134178
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. XM_017594053.1XP_017449542.1  fibulin-5 isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      118399373..118476665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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