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    Hpn hepsin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29135, updated on 18-Apr-2019

    Summary

    Official Symbol
    Hpnprovided by RGD
    Official Full Name
    hepsinprovided by RGD
    Primary source
    RGD:61982
    See related
    Ensembl:ENSRNOG00000021097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    cell surface serine proteinase [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Kidney (RPKM 529.1), Liver (RPKM 485.5) and 1 other tissue See more
    Orthologs

    Genomic context

    See Hpn in Genome Data Viewer
    Location:
    1q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89534112..89549575, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (90688659..90704122, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene leucine-rich repeat LGI family, member 4 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene sodium voltage-gated channel beta subunit 1 Neighboring gene GRAM domain containing 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    basement membrane disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    basement membrane disassembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    basement membrane disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cochlea morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of sound ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epithelium development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of alkaline phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pilomotor reflex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pilomotor reflex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation by host of viral transcription IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation by host of viral transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of plasminogen activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of thyroid hormone generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to thyroid hormone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to thyroid hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine protease hepsin
    Names
    hepsin (transmembrane protease, serine 1)
    NP_058808.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017112.1NP_058808.1  serine protease hepsin precursor

      See identical proteins and their annotated locations for NP_058808.1

      Status: PROVISIONAL

      Source sequence(s)
      X70900
      UniProtKB/Swiss-Prot
      Q05511
      Related
      ENSRNOP00000028644.6, ENSRNOT00000028644.6
      Conserved Domains (3) summary
      smart00020
      Location:161399
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:162399
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09272
      Location:49158
      Hepsin-SRCR; Hepsin, SRCR

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      89534112..89549575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      80705987..80721634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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