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    Dhps deoxyhypusine synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288923, updated on 18-Apr-2019

    Summary

    Official Symbol
    Dhpsprovided by RGD
    Official Full Name
    deoxyhypusine synthaseprovided by RGD
    Primary source
    RGD:1303326
    See related
    Ensembl:ENSRNOG00000004219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    human homolog catalyzes the first step in the post-translational modification of a lysine residue in the precursor eukaryotic initiation factor 5A (eIF5A) to the amino acid hypusine [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 195.8), Muscle (RPKM 182.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Dhps in Genome Data Viewer
    Location:
    19q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26184665..26188755)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (37160288..37164378)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 9 Neighboring gene G protein subunit gamma 14 Neighboring gene WD repeat domain 83 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene mannosidase, alpha, class 2B, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC94237

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    deoxyhypusine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    deoxyhypusine synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deoxyhypusine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-lysine modification to peptidyl-hypusine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-lysine modification to peptidyl-hypusine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermidine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermidine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    deoxyhypusine synthase
    Names
    DHS
    NP_001004207.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004207.1NP_001004207.1  deoxyhypusine synthase

      See identical proteins and their annotated locations for NP_001004207.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079188
      UniProtKB/Swiss-Prot
      Q6AY53
      Related
      ENSRNOP00000005656.3, ENSRNOT00000005656.5
      Conserved Domains (1) summary
      pfam01916
      Location:45351
      DS; Deoxyhypusine synthase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      26184665..26188755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      22640425..22644511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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