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    Pms2 PMS1 homolog 2, mismatch repair system component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288479, updated on 18-Apr-2019

    Summary

    Official Symbol
    Pms2provided by RGD
    Official Full Name
    PMS1 homolog 2, mismatch repair system componentprovided by RGD
    Primary source
    RGD:1305483
    See related
    Ensembl:ENSRNOG00000001040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Thymus (RPKM 72.0), Spleen (RPKM 63.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Pms2 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12714394..12738654, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (14757747..14781994, complement)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated Neighboring gene radial spoke head 10 homolog B Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    MutSalpha complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    single base insertion or deletion binding IEA
    Inferred from Electronic Annotation
    more info
     
    single base insertion or deletion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of isotype switching to IgA isotypes ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    somatic hypermutation of immunoglobulin genes IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    somatic recombination of immunoglobulin gene segments ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MutLalpha complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    mismatch repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mismatch repair endonuclease PMS2
    Names
    PMS2 postmeiotic segregation increased 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105908.1NP_001099378.1  mismatch repair endonuclease PMS2

      See identical proteins and their annotated locations for NP_001099378.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/TrEMBL
      D4A360
      Related
      ENSRNOP00000061927.1, ENSRNOT00000067021.2
      Conserved Domains (2) summary
      smart00853
      Location:358501
      MutL_C; MutL C terminal dimerisation domain
      cl02783
      Location:153
      TopoII_MutL_Trans; MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      12714394..12738654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248862.3XP_006248924.1  mismatch repair endonuclease PMS2 isoform X1

      See identical proteins and their annotated locations for XP_006248924.1

      UniProtKB/TrEMBL
      B1H246
      Related
      ENSRNOP00000069740.1, ENSRNOT00000078603.2
      Conserved Domains (4) summary
      smart00853
      Location:669812
      MutL_C; MutL C terminal dimerisation domain
      cd03484
      Location:223364
      MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
      TIGR00585
      Location:13344
      mutl; DNA mismatch repair protein MutL
      cl00075
      Location:34148
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    2. XM_017598288.1XP_017453777.1  mismatch repair endonuclease PMS2 isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      12474260..12498506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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