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    Coasy Coenzyme A synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287711, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Coasyprovided by RGD
    Official Full Name
    Coenzyme A synthaseprovided by RGD
    Primary source
    RGD:1549767
    See related
    Ensembl:ENSRNOG00000019918 AllianceGenome:RGD:1549767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 152.5), Liver (RPKM 149.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86514850..86519130)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86014566..86018849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88992413..88996677)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene MAX dimerization protein MLX Neighboring gene PSMC3 interacting protein Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation. Dusi S, et al. Am J Hum Genet, 2014 Jan 2. PMID 24360804, Free PMC Article
    2. Identification of a novel CoA synthase isoform, which is primarily expressed in the brain. Nemazanyy I, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16460672
    3. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis. Zhyvoloup A, et al. J Biol Chem, 2002 Jun 21. PMID 11980892
    4. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). Aghajanian S, et al. Biochem J, 2002 Jul 1. PMID 11994049, Free PMC Article
    5. Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism. Nemazanyy I, et al. FEBS Lett, 2004 Dec 17. PMID 15589845

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94749

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dephospho-CoA kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional coenzyme A synthase
    Names
    CoA synthase
    NP_001006955.1
    XP_006247338.1
    XP_038941544.1
    XP_063124807.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006954.1 → NP_001006955.1  bifunctional coenzyme A synthase precursor

      See identical proteins and their annotated locations for NP_001006955.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083781
      UniProtKB/TrEMBL
      Q5XIA5
      Related
      ENSRNOP00000027061.2, ENSRNOT00000027061.4
      Conserved Domains (2) summary
      cd02164
      Location:192 → 338
      PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
      cd02022
      Location:359 → 535
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86514850..86519130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247276.5 → XP_006247338.1  bifunctional coenzyme A synthase isoform X1

      See identical proteins and their annotated locations for XP_006247338.1

      UniProtKB/TrEMBL
      Q5XIA5
      Conserved Domains (2) summary
      cd02164
      Location:192 → 338
      PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
      cd02022
      Location:359 → 535
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

    2. XM_039085616.2 → XP_038941544.1  bifunctional coenzyme A synthase isoform X2

      Conserved Domains (2) summary
      cd02022
      Location:65 → 241
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
      cl00015
      Location:1 → 44
      nt_trans; nucleotidyl transferase superfamily

    3. XM_063268737.1 → XP_063124807.1  bifunctional coenzyme A synthase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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