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    Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286964, updated on 21-Jul-2018

    Summary

    Official Symbol
    Hsd17b6provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 6provided by RGD
    Primary source
    RGD:708343
    See related
    Ensembl:ENSRNOG00000002597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hsd17b9
    Summary
    catalyzes the oxidation of 3alpha-adiol to androsterone in androgen metabolism [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 1181.4) See more

    Genomic context

    See Hsd17b6 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2412370..2431249, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (2390308..2409187, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 36, C3H1 type-like 2-like Neighboring gene uncharacterized LOC102551803 Neighboring gene DNA primase subunit 1 Neighboring gene nascent polypeptide associated complex subunit alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Clone Names

    • MGC108559

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    estradiol 17-beta-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    retinol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    testosterone dehydrogenase (NAD+) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    androgen metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    17-beta-hydroxysteroid dehydrogenase type 6
    Names
    17-beta-HSD 6
    17-beta-HSD6
    3-alpha->beta-HSE
    3-alpha->beta-hydroxysteroid epimerase
    hydroxysteroid (17-beta) dehydrogenase 9
    oxidative 17 beta hydroxysteroid dehydrogenase type 6
    oxidative 3-alpha hydroxysteroid dehydrogenase
    NP_775427.1
    XP_017450177.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173305.1NP_775427.1  17-beta-hydroxysteroid dehydrogenase type 6

      See identical proteins and their annotated locations for NP_775427.1

      Status: PROVISIONAL

      Source sequence(s)
      U89280
      UniProtKB/Swiss-Prot
      O54753
      Conserved Domains (2) summary
      PRK06182
      Location:40313
      PRK06182; short chain dehydrogenase; Validated
      cl21454
      Location:40316
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      2412370..2431249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594688.1XP_017450177.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      UniProtKB/TrEMBL
      F1LP50
      Related
      ENSRNOP00000003498.6, ENSRNOT00000003498.6
      Conserved Domains (2) summary
      PRK06182
      Location:30303
      PRK06182; short chain dehydrogenase; Validated
      cl21454
      Location:30306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      310880..321035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. NW_001089423.1 Alternate Rn_Celera

      Range
      637..4026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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