Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF326 zinc finger protein 326 [ Homo sapiens (human) ]

    Gene ID: 284695, updated on 2-Oct-2018

    Summary

    Official Symbol
    ZNF326provided by HGNC
    Official Full Name
    zinc finger protein 326provided by HGNC
    Primary source
    HGNC:HGNC:14104
    See related
    Ensembl:ENSG00000162664 MIM:614601; Vega:OTTHUMG00000010675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIRD; ZAN75; Zfp326; dJ871E2.1
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.2), endometrium (RPKM 3.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF326 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (89995095..90035531)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (90460678..90494101)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 272 Neighboring gene gem nuclear organelle associated protein 8 pseudogene 4 Neighboring gene uncharacterized LOC105378848 Neighboring gene uncharacterized LOC105378849 Neighboring gene RNA, U6 small nuclear 695, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Zinc finger protein 326 (ZNF326) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20403, MGC61591

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of DNA-templated transcription, elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    DBIRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DBIRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    DBIRD complex subunit ZNF326
    Names
    ZNF-protein interacting with nuclear mRNPs and DBC1
    dJ871E2.1 (novel protein (ortholog of mouse zinc finger protein Zan75))
    zinc finger protein interacting with mRNPs and DBC1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320185.1NP_001307114.1  DBIRD complex subunit ZNF326 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK303707, AL161797, BC014899, BU676987, CN299618
      Consensus CDS
      CCDS81351.1
      UniProtKB/Swiss-Prot
      Q5BKZ1
      UniProtKB/TrEMBL
      A0A0A0MRN4
      Related
      ENSP00000359476.2, OTTHUMP00000012404, ENST00000370447.3, OTTHUMT00000029431
      Conserved Domains (1) summary
      pfam04988
      Location:223388
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    2. NM_181781.3NP_861446.2  DBIRD complex subunit ZNF326 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK303707, AL161797, BC014899, BC038454, BU676987, CN299618
      UniProtKB/Swiss-Prot
      Q5BKZ1
      Conserved Domains (1) summary
      pfam04988
      Location:106271
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    3. NM_182975.3NP_892020.1  DBIRD complex subunit ZNF326 isoform 3

      See identical proteins and their annotated locations for NP_892020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' exon structure and differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK000410, BC053888, CN299618
      Consensus CDS
      CCDS728.1
      UniProtKB/Swiss-Prot
      Q5BKZ1
      Related
      ENSP00000355318.5, OTTHUMP00000012403, ENST00000361911.9, OTTHUMT00000029430
    4. NM_182976.3NP_892021.1  DBIRD complex subunit ZNF326 isoform 1

      See identical proteins and their annotated locations for NP_892021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK303707, AL161797, BC090866, BU676987, CN299618
      Consensus CDS
      CCDS727.1
      UniProtKB/Swiss-Prot
      Q5BKZ1
      Related
      ENSP00000340796.4, OTTHUMP00000012401, ENST00000340281.8, OTTHUMT00000029428
      Conserved Domains (1) summary
      pfam04988
      Location:312477
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      89995095..90035531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541290.2XP_011539592.1  DBIRD complex subunit ZNF326 isoform X1

      See identical proteins and their annotated locations for XP_011539592.1

      UniProtKB/Swiss-Prot
      Q5BKZ1
      Conserved Domains (1) summary
      pfam04988
      Location:106271
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    2. XM_005270779.4XP_005270836.1  DBIRD complex subunit ZNF326 isoform X1

      See identical proteins and their annotated locations for XP_005270836.1

      UniProtKB/Swiss-Prot
      Q5BKZ1
      Conserved Domains (1) summary
      pfam04988
      Location:106271
      AKAP95; A-kinase anchoring protein 95 (AKAP95)
    Support Center