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    GPR19 G protein-coupled receptor 19 [ Homo sapiens (human) ]

    Gene ID: 2842, updated on 2-Oct-2018

    Summary

    Official Symbol
    GPR19provided by HGNC
    Official Full Name
    G protein-coupled receptor 19provided by HGNC
    Primary source
    HGNC:HGNC:4473
    See related
    Ensembl:ENSG00000183150 MIM:602927; Vega:OTTHUMG00000168705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See GPR19 in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (12659691..12717786, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12813995..12849121, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984486 Neighboring gene ribosomal protein L21 pseudogene 136 Neighboring gene cAMP responsive element binding protein like 2 Neighboring gene uncharacterized LOC105369663 Neighboring gene uncharacterized LOC107984129 Neighboring gene cyclin dependent kinase inhibitor 1B Neighboring gene apolipoprotein L domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    probable G-protein coupled receptor 19
    Names
    GPR-NGA

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006143.2NP_006134.1  probable G-protein coupled receptor 19

      See identical proteins and their annotated locations for NP_006134.1

      Status: VALIDATED

      Source sequence(s)
      AK074729, AK096388, DB022290
      Consensus CDS
      CCDS8652.1
      UniProtKB/Swiss-Prot
      Q15760
      UniProtKB/TrEMBL
      Q6IBH2
      Related
      ENSP00000333744.2, ENST00000332427.6
      Conserved Domains (2) summary
      pfam00001
      Location:82330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72258
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      12659691..12717786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019216.2XP_016874705.1  probable G-protein coupled receptor 19 isoform X2

      UniProtKB/Swiss-Prot
      Q15760
      Conserved Domains (2) summary
      pfam00001
      Location:82330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72258
      7tm_4; Olfactory receptor
    2. XM_011520623.3XP_011518925.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_011518925.1

      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
    3. XM_011520624.2XP_011518926.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_011518926.1

      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
    4. XM_017019212.1XP_016874701.1  probable G-protein coupled receptor 19 isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
    5. XM_011520625.2XP_011518927.1  probable G-protein coupled receptor 19 isoform X2

      See identical proteins and their annotated locations for XP_011518927.1

      UniProtKB/Swiss-Prot
      Q15760
      Conserved Domains (2) summary
      pfam00001
      Location:82330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72258
      7tm_4; Olfactory receptor
    6. XM_017019213.1XP_016874702.1  probable G-protein coupled receptor 19 isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
    7. XM_017019214.1XP_016874703.1  probable G-protein coupled receptor 19 isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
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