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    ADAM10 ADAM metallopeptidase domain 10 [ Bos taurus (cattle) ]

    Gene ID: 282132, updated on 9-Jan-2020

    Summary

    Official Symbol
    ADAM10provided by VGNC
    Official Full Name
    ADAM metallopeptidase domain 10provided by VGNC
    Primary source
    VGNC:VGNC:25604
    See related
    BGD:BT15627; Ensembl:ENSBTAG00000005481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADAM 10
    Orthologs

    Genomic context

    See ADAM10 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 10 NC_037337.1 (51536002..51679260)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 10 AC_000167.1 (51598073..51739157)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene iron-sulfur cluster scaffold homolog (E. coli)-like Neighboring gene lipase C, hepatic type Neighboring gene uncharacterized LOC112448468 Neighboring gene 5S ribosomal RNA Neighboring gene methylosome subunit pICln pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    PMA-inducible membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    constitutive protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    monocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pore complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi-associated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    tetraspanin-enriched microdomain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    myelin-associated metalloproteinase
    NP_776921.1
    XP_024853043.1
    XP_024853044.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174496.3NP_776921.1  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

      See identical proteins and their annotated locations for NP_776921.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000010
      UniProtKB/Swiss-Prot
      Q10741
      Related
      ENSBTAP00000056919.1, ENSBTAT00000075105.1
      Conserved Domains (4) summary
      smart00050
      Location:466545
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220459
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:46146
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:240444
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      51536002..51679260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997275.1XP_024853043.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      Conserved Domains (3) summary
      smart00050
      Location:392471
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:146385
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:267
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_024997276.1XP_024853044.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      Conserved Domains (3) summary
      smart00050
      Location:392471
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:146385
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:267
      Pep_M12B_propep; Reprolysin family propeptide
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