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    Dcaf11 DDB1 and CUL4 associated factor 11 [ Mus musculus (house mouse) ]

    Gene ID: 28199, updated on 9-Sep-2018

    Summary

    Official Symbol
    Dcaf11provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 11provided by MGI
    Primary source
    MGI:MGI:90168
    See related
    Ensembl:ENSMUSG00000022214 Vega:OTTMUSG00000027921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLO14; Wdr23; C76035; Dacf11; D14Ucla1; 0710008A13Rik
    Expression
    Ubiquitous expression in liver adult (RPKM 65.2), kidney adult (RPKM 42.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dcaf11 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (55559953..55570065)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56178869..56188902)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene neural retina leucine zipper gene Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial) Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 11
    Names
    WD repeat domain 23
    WD repeat-containing protein 23

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199009.1NP_001185938.1  DDB1- and CUL4-associated factor 11

      See identical proteins and their annotated locations for NP_001185938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033540, AK150183, DV648268
      Consensus CDS
      CCDS27115.1
      UniProtKB/Swiss-Prot
      Q91VU6
      UniProtKB/TrEMBL
      Q3UD98
      Related
      ENSMUSP00000072344.4, OTTMUSP00000035085, ENSMUST00000072530.10, OTTMUST00000069153
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_133734.3NP_598495.1  DDB1- and CUL4-associated factor 11

      See identical proteins and their annotated locations for NP_598495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK033540, BB845333
      Consensus CDS
      CCDS27115.1
      UniProtKB/Swiss-Prot
      Q91VU6
      Related
      ENSMUSP00000113014.1, OTTMUSP00000035082, ENSMUST00000117236.7, OTTMUST00000069150
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_037572.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple splice site differences at the 5' end, compared to variant 1, which result in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK158784, BB845333
      Related
      ENSMUST00000150019.7, OTTMUST00000069151

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      55559953..55570065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519081.3XP_006519144.1  DDB1- and CUL4-associated factor 11 isoform X1

      See identical proteins and their annotated locations for XP_006519144.1

      UniProtKB/Swiss-Prot
      Q91VU6
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006519083.3XP_006519146.1  DDB1- and CUL4-associated factor 11 isoform X1

      See identical proteins and their annotated locations for XP_006519146.1

      UniProtKB/Swiss-Prot
      Q91VU6
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006519085.3XP_006519148.1  DDB1- and CUL4-associated factor 11 isoform X1

      See identical proteins and their annotated locations for XP_006519148.1

      UniProtKB/Swiss-Prot
      Q91VU6
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_006519084.3XP_006519147.1  DDB1- and CUL4-associated factor 11 isoform X1

      See identical proteins and their annotated locations for XP_006519147.1

      UniProtKB/Swiss-Prot
      Q91VU6
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_006519087.3XP_006519150.1  DDB1- and CUL4-associated factor 11 isoform X2

      See identical proteins and their annotated locations for XP_006519150.1

      UniProtKB/Swiss-Prot
      Q91VU6
      UniProtKB/TrEMBL
      Q3TYA0
      Conserved Domains (3) summary
      COG2319
      Location:132495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:177219
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:136467
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_006519088.3XP_006519151.1  DDB1- and CUL4-associated factor 11 isoform X2

      See identical proteins and their annotated locations for XP_006519151.1

      UniProtKB/Swiss-Prot
      Q91VU6
      UniProtKB/TrEMBL
      Q3TYA0
      Conserved Domains (3) summary
      COG2319
      Location:132495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:177219
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:136467
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_006519090.3XP_006519153.1  DDB1- and CUL4-associated factor 11 isoform X2

      See identical proteins and their annotated locations for XP_006519153.1

      UniProtKB/Swiss-Prot
      Q91VU6
      UniProtKB/TrEMBL
      Q3TYA0
      Conserved Domains (3) summary
      COG2319
      Location:132495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:177219
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:136467
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. XM_006519091.3XP_006519154.1  DDB1- and CUL4-associated factor 11 isoform X2

      See identical proteins and their annotated locations for XP_006519154.1

      UniProtKB/Swiss-Prot
      Q91VU6
      UniProtKB/TrEMBL
      Q3TYA0
      Conserved Domains (3) summary
      COG2319
      Location:132495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:177219
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:136467
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    9. XM_006519092.3XP_006519155.1  DDB1- and CUL4-associated factor 11 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:55327
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:5693
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:55299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. XM_006519089.2XP_006519152.1  DDB1- and CUL4-associated factor 11 isoform X2

      See identical proteins and their annotated locations for XP_006519152.1

      UniProtKB/Swiss-Prot
      Q91VU6
      UniProtKB/TrEMBL
      Q3TYA0
      Conserved Domains (3) summary
      COG2319
      Location:132495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:177219
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:136467
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    11. XM_006519086.3XP_006519149.1  DDB1- and CUL4-associated factor 11 isoform X1

      See identical proteins and their annotated locations for XP_006519149.1

      UniProtKB/Swiss-Prot
      Q91VU6
      Conserved Domains (3) summary
      COG2319
      Location:176539
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:221263
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:171511
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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