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    PLCD1 phospholipase C delta 1 [ Bos taurus (cattle) ]

    Gene ID: 281986, updated on 2-Oct-2018

    Summary

    Official Symbol
    PLCD1provided by VGNC
    Official Full Name
    phospholipase C delta 1provided by VGNC
    Primary source
    VGNC:VGNC:32984
    See related
    BGD:BT10287; Ensembl:ENSBTAG00000037726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See PLCD1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 22 NC_037349.1 (11459790..11481187, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (11497066..11518465, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase like Neighboring gene microRNA 26a-1 Neighboring gene microRNA 26c Neighboring gene villin like Neighboring gene DLEC1, cilia and flagella associated protein Neighboring gene acetyl-CoA acyltransferase 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activating protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
    Names
    PLC-III
    PLC-delta-1
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-delta-1
    phospholipase C-III
    NP_001075045.1
    XP_005222429.1
    XP_010815710.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081576.1NP_001075045.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

      Status: PROVISIONAL

      Source sequence(s)
      BC133304
      UniProtKB/Swiss-Prot
      P10895
      Related
      ENSBTAP00000049395.1, ENSBTAT00000052073.1
      Conserved Domains (4) summary
      cd00275
      Location:628755
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:295596
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      cd13363
      Location:22139
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16217
      Location:144283
      EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      11459790..11481187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010817408.2XP_010815710.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2

      Conserved Domains (6) summary
      cd00275
      Location:570697
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:237538
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      PLN02228
      Location:155697
      PLN02228; Phosphoinositide phospholipase C
      pfam09279
      Location:155237
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam14788
      Location:101150
      EF-hand_10; EF hand
      cl17171
      Location:181
      PH-like; Pleckstrin homology-like domain
    2. XM_005222372.3XP_005222429.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1

      Conserved Domains (4) summary
      cd00275
      Location:653780
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08593
      Location:320621
      PI-PLCc_delta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta
      cd13363
      Location:47164
      PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
      cd16217
      Location:169308
      EFh_PI-PLCdelta1; EF-hand motif found in phosphoinositide phospholipase C delta 1 (PI-PLC-delta1)
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