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    PDE5A phosphodiesterase 5A [ Bos taurus (cattle) ]

    Gene ID: 281972, updated on 14-Jan-2019

    Summary

    Official Symbol
    PDE5Aprovided by VGNC
    Official Full Name
    phosphodiesterase 5Aprovided by VGNC
    Primary source
    VGNC:VGNC:32678
    See related
    BGD:BT10779; Ensembl:ENSBTAG00000024888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See PDE5A in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 6 NC_037333.1 (5745681..5894235)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 6 AC_000163.1 (6874055..6988848) , (7036105..7070187)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC112447030 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC112447029 Neighboring gene uncharacterized LOC112447031 Neighboring gene uncharacterized LOC112447032 Neighboring gene fatty acid binding protein 2

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3',5'-cyclic-GMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cGMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cyclic-nucleotide phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nitric oxide mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    relaxation of cardiac muscle IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cGMP-specific 3',5'-cyclic phosphodiesterase
    Names
    CGB-PDE
    cGMP-binding cGMP-specific phosphodiesterase
    phosphodiesterase 5A, cGMP-specific
    NP_776842.1
    XP_024848769.1
    XP_024848770.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174417.2NP_776842.1  cGMP-specific 3',5'-cyclic phosphodiesterase

      See identical proteins and their annotated locations for NP_776842.1

      Status: PROVISIONAL

      Source sequence(s)
      L16545
      UniProtKB/Swiss-Prot
      Q28156
      Related
      ENSBTAP00000014479.4, ENSBTAT00000014479.5
      Conserved Domains (2) summary
      smart00065
      Location:154311
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:602837
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      5745681..5894235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993002.1XP_024848770.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X2

      Related
      ENSBTAP00000068751.1, ENSBTAT00000076917.1
      Conserved Domains (2) summary
      smart00065
      Location:112269
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:560791
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_024993001.1XP_024848769.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1

      Related
      ENSBTAP00000074440.1, ENSBTAT00000075252.1
      Conserved Domains (2) summary
      smart00065
      Location:122279
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:570801
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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