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    MAPT microtubule associated protein tau [ Bos taurus (cattle) ]

    Gene ID: 281296, updated on 12-May-2019

    Summary

    Official Symbol
    MAPTprovided by VGNC
    Official Full Name
    microtubule associated protein tauprovided by VGNC
    Primary source
    VGNC:VGNC:57143
    See related
    BGD:BT14326; Ensembl:ENSBTAG00000017512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    tau
    Orthologs

    Genomic context

    See MAPT in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 19 NC_037346.1 (45884332..46007017)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 19 AC_000176.1 (46593336..46643750)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene cell division cycle 27

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
      Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin 5 (IL-5) ligand belongs to the cytokine superfamily. IL-5 is a glycoprotein which belongs to the cytokine superfamily. It possesses the four helical bundle motifs that is conserved among ...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Kit receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Kit receptor signaling pathway, organism-specific biosystemKit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 r...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch pathway is an evolutionally conserved signaling pathway which plays an important role in diverse developmental and physiological processes. These include cell-fate determination, tissue pat...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Microtubule Cytoskeleton, organism-specific biosystem
      Regulation of Microtubule Cytoskeleton

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC134287

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    apolipoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule lateral binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    axo-dendritic transport IEA
    Inferred from Electronic Annotation
    more info
     
    axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular distribution of mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of establishment of protein localization to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intracellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tubulin deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    protein polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    axoneme IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glial cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neurofibrillary tangle IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear periphery IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    microtubule-associated protein tau
    Names
    PHF-tau
    neurofibrillary tangle protein
    paired helical filament-tau

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174106.2NP_776531.1  microtubule-associated protein tau

      See identical proteins and their annotated locations for NP_776531.1

      Status: PROVISIONAL

      Source sequence(s)
      M26157
      UniProtKB/Swiss-Prot
      P29172
      Related
      ENSBTAP00000054412.1, ENSBTAT00000064492.2
      Conserved Domains (1) summary
      pfam00418
      Location:282311
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      45884332..46007017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979566.1XP_024835334.1  microtubule-associated protein tau isoform X1

      Conserved Domains (2) summary
      pfam00418
      Location:451480
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169424
      Atrophin-1; Atrophin-1 family
    2. XM_024979565.1XP_024835333.1  microtubule-associated protein tau isoform X1

      Related
      ENSBTAP00000023284.6, ENSBTAT00000023284.6
      Conserved Domains (2) summary
      pfam00418
      Location:451480
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169424
      Atrophin-1; Atrophin-1 family
    3. XM_024979572.1XP_024835340.1  microtubule-associated protein tau isoform X6

      Conserved Domains (2) summary
      pfam00418
      Location:393422
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:111366
      Atrophin-1; Atrophin-1 family
    4. XM_024979570.1XP_024835338.1  microtubule-associated protein tau isoform X4

      Conserved Domains (2) summary
      pfam00418
      Location:451480
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169424
      Atrophin-1; Atrophin-1 family
    5. XM_024979573.1XP_024835341.1  microtubule-associated protein tau isoform X7

      Conserved Domains (2) summary
      pfam00418
      Location:385414
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169361
      Atrophin-1; Atrophin-1 family
    6. XM_024979569.1XP_024835337.1  microtubule-associated protein tau isoform X3

      Conserved Domains (2) summary
      pfam00418
      Location:422451
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:140395
      Atrophin-1; Atrophin-1 family
    7. XM_024979568.1XP_024835336.1  microtubule-associated protein tau isoform X2

      Related
      ENSBTAP00000054994.2, ENSBTAT00000064966.2
      Conserved Domains (2) summary
      pfam00418
      Location:433462
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169406
      Atrophin-1; Atrophin-1 family
    8. XM_024979571.1XP_024835339.1  microtubule-associated protein tau isoform X5

      Conserved Domains (2) summary
      pfam00418
      Location:433462
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169406
      Atrophin-1; Atrophin-1 family
    9. XM_024979574.1XP_024835342.1  microtubule-associated protein tau isoform X8

      Conserved Domains (2) summary
      pfam00418
      Location:367396
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:100354
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    10. XM_024979575.1XP_024835343.1  microtubule-associated protein tau isoform X9

      Conserved Domains (2) summary
      pfam00418
      Location:348377
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:38321
      Atrophin-1; Atrophin-1 family
    11. XM_024979578.1XP_024835346.1  microtubule-associated protein tau isoform X12

      Conserved Domains (2) summary
      pfam00418
      Location:290319
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:71263
      Atrophin-1; Atrophin-1 family
    12. XM_024979576.1XP_024835344.1  microtubule-associated protein tau isoform X10

      Conserved Domains (2) summary
      pfam00418
      Location:319348
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:38292
      Atrophin-1; Atrophin-1 family
    13. XM_024979577.1XP_024835345.1  microtubule-associated protein tau isoform X11

      Conserved Domains (2) summary
      pfam00418
      Location:301330
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:23274
      Atrophin-1; Atrophin-1 family
    14. XM_024979581.1XP_024835349.1  microtubule-associated protein tau isoform X15

      Related
      ENSBTAP00000056547.1, ENSBTAT00000065660.2
      Conserved Domains (2) summary
      pfam00418
      Location:253282
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26386
      Location:76225
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    15. XM_024979579.1XP_024835347.1  microtubule-associated protein tau isoform X13

      Conserved Domains (2) summary
      pfam00418
      Location:272301
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl27975
      Location:5248
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    16. XM_024979585.1XP_024835353.1  microtubule-associated protein tau isoform X18

      Conserved Domains (2) summary
      pfam00418
      Location:224253
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26386
      Location:47196
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    17. XM_024979591.1XP_024835359.1  microtubule-associated protein tau isoform X21

      Conserved Domains (2) summary
      pfam00418
      Location:224253
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26386
      Location:47196
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    18. XM_024979580.1XP_024835348.1  microtubule-associated protein tau isoform X14

      Conserved Domains (2) summary
      pfam00418
      Location:264293
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:33251
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    19. XM_024979584.1XP_024835352.1  microtubule-associated protein tau isoform X17

      Conserved Domains (2) summary
      pfam00418
      Location:264293
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:39251
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    20. XM_024979582.1XP_024835350.1  microtubule-associated protein tau isoform X16

      Related
      ENSBTAP00000056351.2, ENSBTAT00000065509.2
      Conserved Domains (2) summary
      pfam00418
      Location:235264
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:22222
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    21. XM_024979586.1XP_024835354.1  microtubule-associated protein tau isoform X19

      Conserved Domains (2) summary
      pfam00418
      Location:206235
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam11702
      Location:79193
      DUF3295; Protein of unknown function (DUF3295)
    22. XM_024979589.1XP_024835357.1  microtubule-associated protein tau isoform X20

      Conserved Domains (2) summary
      pfam00418
      Location:235264
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:22222
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    23. XM_024979588.1XP_024835356.1  microtubule-associated protein tau isoform X19

      Conserved Domains (2) summary
      pfam00418
      Location:206235
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam11702
      Location:79193
      DUF3295; Protein of unknown function (DUF3295)
    24. XM_024979567.1XP_024835335.1  microtubule-associated protein tau isoform X1

      Conserved Domains (2) summary
      pfam00418
      Location:451480
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:169424
      Atrophin-1; Atrophin-1 family
    25. XM_024979587.1XP_024835355.1  microtubule-associated protein tau isoform X19

      Conserved Domains (2) summary
      pfam00418
      Location:206235
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam11702
      Location:79193
      DUF3295; Protein of unknown function (DUF3295)
    26. XM_024979590.1XP_024835358.1  microtubule-associated protein tau isoform X20

      Related
      ENSBTAP00000040320.4, ENSBTAT00000042687.4
      Conserved Domains (2) summary
      pfam00418
      Location:235264
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:22222
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    27. XM_024979583.1XP_024835351.1  microtubule-associated protein tau isoform X16

      Conserved Domains (2) summary
      pfam00418
      Location:235264
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl28033
      Location:22222
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
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