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    FECH ferrochelatase [ Bos taurus (cattle) ]

    Gene ID: 281158, updated on 27-Aug-2018

    Summary

    Official Symbol
    FECHprovided by VGNC
    Official Full Name
    ferrochelataseprovided by VGNC
    Primary source
    VGNC:VGNC:28943
    See related
    BGD:BT10042; Ensembl:ENSBTAG00000006393
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See FECH in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 24 NC_037351.1 (56787248..56822085, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 24 AC_000181.1 (57298434..57333273, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene one cut homeobox 2 Neighboring gene U6 spliceosomal RNA Neighboring gene asparaginyl-tRNA synthetase

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protoporphyrinogen IX metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ferrochelatase, mitochondrial
    Names
    heme synthase
    heme synthetase
    protoheme ferro-lyase
    protoporphyria
    NP_776479.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174054.2NP_776479.1  ferrochelatase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_776479.1

      Status: PROVISIONAL

      Source sequence(s)
      L34173
      UniProtKB/Swiss-Prot
      P22600
      Related
      ENSBTAP00000008384.2, ENSBTAT00000008384.2
      Conserved Domains (3) summary
      cd00419
      Location:228365
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:62223
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:62382
      Ferrochelatase; Ferrochelatase

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      56787248..56822085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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