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    CCN2 cellular communication network factor 2 [ Bos taurus (cattle) ]

    Gene ID: 281103, updated on 23-Oct-2018

    Summary

    Official Symbol
    CCN2provided by VGNC
    Official Full Name
    cellular communication network factor 2provided by VGNC
    Primary source
    VGNC:VGNC:27794
    See related
    BGD:BT12273; Ensembl:ENSBTAG00000006367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CTGF
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs

    Genomic context

    See CCN2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 9 NC_037336.1 (69887199..69890434, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 9 AC_000166.1 (70873216..70876451, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene uncharacterized LOC101904601 Neighboring gene monooxygenase DBH like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene kynurenine--oxoglutarate transaminase 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138005

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage condensation IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    chondrocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    connective tissue growth factor
    Names
    CCN family member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174030.2NP_776455.1  connective tissue growth factor precursor

      See identical proteins and their annotated locations for NP_776455.1

      Status: PROVISIONAL

      Source sequence(s)
      AF000137
      UniProtKB/Swiss-Prot
      O18739
      Related
      ENSBTAP00000008357.5, ENSBTAT00000008357.5
      Conserved Domains (3) summary
      smart00214
      Location:104162
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:3082
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:253345
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      69887199..69890434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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