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    ACAN aggrecan [ Bos taurus (cattle) ]

    Gene ID: 280985, updated on 2-Oct-2018

    Summary

    Official Symbol
    ACANprovided by VGNC
    Official Full Name
    aggrecanprovided by VGNC
    Primary source
    VGNC:VGNC:25525
    See related
    Ensembl:ENSBTAG00000016158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    AGC1
    Orthologs

    Genomic context

    See ACAN in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 21 NC_037348.1 (20377694..20447099)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 21 AC_000178.1 (20800158..20869563)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene myeloid-associated differentiation marker-like Neighboring gene myeloid-associated differentiation marker Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene milk fat globule-EGF factor 8 protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
      Endochondral Ossification, organism-specific biosystemEndochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone. During endochondral ossificatio...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    aggrecan core protein
    Names
    CSPCP
    aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
    aggrecan epidermal growth factor-like domain-1
    cartilage-specific proteoglycan core protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173981.2NP_776406.1  aggrecan core protein precursor

      See identical proteins and their annotated locations for NP_776406.1

      Status: PROVISIONAL

      Source sequence(s)
      U76615
      UniProtKB/Swiss-Prot
      P13608
      Related
      ENSBTAP00000021514.4, ENSBTAT00000021514.4
      Conserved Domains (6) summary
      cd05900
      Location:43154
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:22442300
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:21172240
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      smart00410
      Location:36150
      IG_like; Immunoglobulin like
      cd03517
      Location:153247
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:254349
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      20377694..20447099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981590.1XP_024837358.1  aggrecan core protein isoform X3

      Conserved Domains (9) summary
      cd05900
      Location:43154
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:22832339
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:21562279
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      cd00054
      Location:21192150
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:153247
      Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
      cd03520
      Location:254349
      Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
      cl25496
      Location:18232125
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl26018
      Location:11621333
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26464
      Location:686971
      Atrophin-1; Atrophin-1 family
    2. XM_024981588.1XP_024837356.1  aggrecan core protein isoform X1

      Conserved Domains (10) summary
      cd05900
      Location:43154
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:22832339
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:21562279
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      cd00054
      Location:21142150
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:153247
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:254349
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cl25495
      Location:19262064
      Endomucin; Endomucin
      cl25496
      Location:18232110
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl26018
      Location:11621333
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26464
      Location:686971
      Atrophin-1; Atrophin-1 family
    3. XM_024981589.1XP_024837357.1  aggrecan core protein isoform X2

      Conserved Domains (9) summary
      cd05900
      Location:43154
      Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
      cd00033
      Location:22452301
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:21182241
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      TIGR00864
      Location:19902239
      PCC; polycystin cation channel protein
      cd03517
      Location:153247
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:254349
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cl25496
      Location:18232110
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl26018
      Location:11621333
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26464
      Location:686971
      Atrophin-1; Atrophin-1 family
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