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    LIF LIF, interleukin 6 family cytokine [ Bos taurus (cattle) ]

    Gene ID: 280840, updated on 2-Oct-2018

    Summary

    Official Symbol
    LIFprovided by VGNC
    Official Full Name
    LIF, interleukin 6 family cytokineprovided by VGNC
    Primary source
    VGNC:VGNC:30880
    See related
    BGD:BT16756; Ensembl:ENSBTAG00000007424
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See LIF in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 17 NC_037344.1 (69261182..69277913, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 17 AC_000174.1 (71412159..71429063, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 3 Neighboring gene HORMA domain containing 2 Neighboring gene uncharacterized LOC104974701 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene oncostatin M

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    lung lobe morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lung vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone H3-K27 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of metanephric nephron tubule epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    spongiotrophoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leukemia inhibitory factor
    Names
    bLIF
    cholinergic differentiation factor
    leukemia inhibitory factor (cholinergic differentiation factor)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173931.1NP_776356.1  leukemia inhibitory factor precursor

      See identical proteins and their annotated locations for NP_776356.1

      Status: PROVISIONAL

      Source sequence(s)
      U65394
      UniProtKB/Swiss-Prot
      Q27956
      Related
      ENSBTAP00000009761.4, ENSBTAT00000009761.4
      Conserved Domains (1) summary
      smart00080
      Location:34191
      LIF_OSM; leukemia inhibitory factor

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      69261182..69277913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015475541.2XP_015331027.1  leukemia inhibitory factor isoform X1

      UniProtKB/Swiss-Prot
      Q27956
      Conserved Domains (1) summary
      smart00080
      Location:34191
      LIF_OSM; leukemia inhibitory factor
    2. XM_005218020.4XP_005218077.1  leukemia inhibitory factor isoform X1

      See identical proteins and their annotated locations for XP_005218077.1

      UniProtKB/Swiss-Prot
      Q27956
      Conserved Domains (1) summary
      smart00080
      Location:34191
      LIF_OSM; leukemia inhibitory factor
    3. XM_024976997.1XP_024832765.1  leukemia inhibitory factor isoform X1

      Conserved Domains (1) summary
      smart00080
      Location:34191
      LIF_OSM; leukemia inhibitory factor
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