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    KIT KIT proto-oncogene receptor tyrosine kinase [ Bos taurus (cattle) ]

    Gene ID: 280832, updated on 2-Oct-2018

    Summary

    Official Symbol
    KITprovided by VGNC
    Official Full Name
    KIT proto-oncogene receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:30618
    See related
    BGD:BT11344; Ensembl:ENSBTAG00000002699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    c-kit
    Orthologs

    Genomic context

    See KIT in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 6 NC_037333.1 (70166681..70254049)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 6 AC_000163.1 (71796318..71917436)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene mitochondrial pyruvate carrier 2 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112447081 Neighboring gene mitochondrial-processing peptidase subunit beta-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Fc receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Kit signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin cytoskeleton reorganization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to thyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    detection of mechanical stimulus involved in sensory perception of sound ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    digestive tract development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ectopic germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    erythropoietin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glycosphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    immature B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lymphoid progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mast cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    megakaryocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    melanocyte adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    melanocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    melanocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    myeloid progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pigmentation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    response to radiation IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mast/stem cell growth factor receptor Kit
    Names
    SCFR
    c-kit receptor
    mast cell growth factor receptor
    proto-oncogene c-Kit
    proto-oncogene tyrosine-protein kinase Kit
    tyrosine-protein kinase Kit
    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    NP_001159956.1
    XP_005207994.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166484.1NP_001159956.1  mast/stem cell growth factor receptor Kit precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000006
      Related
      ENSBTAP00000003498.5, ENSBTAT00000003498.5
      Conserved Domains (7) summary
      cd00096
      Location:427506
      Ig; Immunoglobulin domain
      cd05860
      Location:312412
      Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
      smart00409
      Location:427506
      IG; Immunoglobulin
      smart00410
      Location:220308
      IG_like; Immunoglobulin like
      cd05104
      Location:554929
      PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
      pfam00047
      Location:216306
      ig; Immunoglobulin domain
      pfam07714
      Location:590925
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      70166681..70254049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005207937.4XP_005207994.2  mast/stem cell growth factor receptor Kit isoform X1

      Conserved Domains (4) summary
      cd05104
      Location:550925
      PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
      pfam00047
      Location:216306
      ig; Immunoglobulin domain
      cd00096
      Location:427506
      Ig; Immunoglobulin domain
      cd05860
      Location:312412
      Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
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