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    Inpp4a inositol polyphosphate-4-phosphatase, type I [ Mus musculus (house mouse) ]

    Gene ID: 269180, updated on 31-Jan-2019

    Summary

    Official Symbol
    Inpp4aprovided by MGI
    Official Full Name
    inositol polyphosphate-4-phosphatase, type Iprovided by MGI
    Primary source
    MGI:MGI:1931123
    See related
    Ensembl:ENSMUSG00000026113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    107kDa; R74740; 9630012D15; D130048C09Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 12.1), frontal lobe adult (RPKM 10.4) and 26 other tissues See more
    Orthologs

    Genomic context

    See Inpp4a in Genome Data Viewer
    Location:
    1 B; 1 15.46 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (37299838..37410740)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (37356738..37467581)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene predicted gene, 37020 Neighboring gene cyclic nucleotide gated channel alpha 3 Neighboring gene RIKEN cDNA 4930439A04 gene Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    polyphosphate catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    type I inositol 3,4-bisphosphate 4-phosphatase
    NP_001277726.1
    NP_001277727.1
    NP_001277728.1
    NP_084542.2
    NP_766559.2
    XP_006496069.1
    XP_006496071.1
    XP_006496072.1
    XP_006496073.1
    XP_006496074.1
    XP_006496076.1
    XP_006496077.1
    XP_006496078.1
    XP_006496079.1
    XP_006496080.1
    XP_006496081.1
    XP_006496082.1
    XP_006496083.1
    XP_011236827.1
    XP_017176423.1
    XP_017176441.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290797.1NP_001277726.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC084390, AC133096, AF317838, AK035867, AK149414, BY274715
      Consensus CDS
      CCDS69879.1
      UniProtKB/Swiss-Prot
      Q9EPW0
      UniProtKB/TrEMBL
      D3Z230, Q3UEQ1
      Related
      ENSMUSP00000121803.1, ENSMUST00000137266.7
      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    2. NM_001290798.1NP_001277727.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform 4

      See identical proteins and their annotated locations for NP_001277727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC084390, AK035867
      Consensus CDS
      CCDS78570.1
      UniProtKB/Swiss-Prot
      Q9EPW0
      UniProtKB/TrEMBL
      A0A0R4J0Q2
      Related
      ENSMUSP00000057233.8, ENSMUST00000058307.14
    3. NM_001290799.1NP_001277728.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC084390, AK035867
      UniProtKB/Swiss-Prot
      Q9EPW0
      Related
      ENSMUSP00000130443.2, ENSMUST00000168546.2
    4. NM_030266.4NP_084542.2  type I inositol 3,4-bisphosphate 4-phosphatase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses several alternate in-frame splice sites in the coding region, compared to variant 3. The encoded protein (isoform 1) is shorter than isoform 3.
      Source sequence(s)
      AC084390, AC133096, AF317838, AK035867, AK149414, BY274715
      Consensus CDS
      CCDS35539.1
      UniProtKB/Swiss-Prot
      Q9EPW0
      UniProtKB/TrEMBL
      F6V2U0, Q3UEQ1
      Related
      ENSMUSP00000027287.4, ENSMUST00000027287.10
      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    5. NM_172971.3NP_766559.2  type I inositol 3,4-bisphosphate 4-phosphatase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC084390, AK035867
      Consensus CDS
      CCDS35540.1
      UniProtKB/Swiss-Prot
      Q9EPW0
      UniProtKB/TrEMBL
      E9QAD0
      Related
      ENSMUSP00000110583.2, ENSMUST00000114933.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      37299838..37410740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496011.1XP_006496074.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X5

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    2. XM_006496019.1XP_006496082.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X12

      UniProtKB/TrEMBL
      E9Q9A0
      Related
      ENSMUSP00000121518.2, ENSMUST00000136846.7
      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    3. XM_006496013.1XP_006496076.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X6

      UniProtKB/TrEMBL
      D3YUL8
      Related
      ENSMUSP00000123071.1, ENSMUST00000132401.7
      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    4. XM_006496020.1XP_006496083.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X13

      Related
      ENSMUSP00000121107.2, ENSMUST00000140264.7
      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    5. XM_006496006.1XP_006496069.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006496069.1

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    6. XM_006496010.1XP_006496073.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X4

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    7. XM_006496014.1XP_006496077.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X7

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    8. XM_006496017.1XP_006496080.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X10

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    9. XM_006496008.1XP_006496071.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X2

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    10. XM_006496015.1XP_006496078.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X8

      UniProtKB/TrEMBL
      D3YUD3
      Related
      ENSMUSP00000115249.2, ENSMUST00000132615.7
      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    11. XM_006496018.1XP_006496081.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X11

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    12. XM_006496009.1XP_006496072.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X3

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    13. XM_006496016.3XP_006496079.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X9

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    14. XM_017320934.1XP_017176423.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X1

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    15. XM_011238525.2XP_011236827.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011236827.1

      Conserved Domains (1) summary
      cd04048
      Location:44157
      C2A_Copine; C2 domain first repeat in Copine
    16. XM_017320952.1XP_017176441.1  type I inositol 3,4-bisphosphate 4-phosphatase isoform X14

      UniProtKB/TrEMBL
      E9QAD0
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