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    Mpg N-methylpurine-DNA glycosylase [ Mus musculus (house mouse) ]

    Gene ID: 268395, updated on 21-Aug-2018

    Summary

    Official Symbol
    Mpgprovided by MGI
    Official Full Name
    N-methylpurine-DNA glycosylaseprovided by MGI
    Primary source
    MGI:MGI:97073
    See related
    Ensembl:ENSMUSG00000020287 Vega:OTTMUSG00000005371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aag; APNG; Mid1; AI326268; 9830006D05
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.1), genital fat pad adult (RPKM 7.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mpg in Genome Data Viewer
    Location:
    11 A4; 11 18.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (32226505..32232702)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (32126505..32132702)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein 25 (U11/U12) Neighboring gene rhomboid 5 homolog 1 Neighboring gene nitrogen permease regulator-like 3 Neighboring gene hemoglobin X, alpha-like embryonic chain in Hba complex Neighboring gene hemoglobin alpha, adult chain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-3-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-7-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-7-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    alkylbase DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alkylbase DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alkylbase DNA N-glycosylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-3-methyladenine glycosylase
    Names
    3-alkyladenine DNA glycosylase
    3-methyladenine DNA glycosidase
    3-methyladenine DNA glycosylase
    ADPG
    alkylpurine-DNA-N-glycosylase
    NP_034952.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010822.3NP_034952.2  DNA-3-methyladenine glycosylase

      See identical proteins and their annotated locations for NP_034952.2

      Status: VALIDATED

      Source sequence(s)
      AK018694, AL929446, BY309585
      Consensus CDS
      CCDS24520.1
      UniProtKB/Swiss-Prot
      Q04841
      Related
      ENSMUSP00000020528.7, OTTMUSP00000005545, ENSMUST00000020528.13, OTTMUST00000011983
      Conserved Domains (1) summary
      cd00540
      Location:110307
      AAG; Alkyladenine DNA glycosylase catalyzes the first step in base excision repair

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      32226505..32232702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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