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    Cpne1 copine I [ Mus musculus (house mouse) ]

    Gene ID: 266692, updated on 2-Oct-2018

    Summary

    Official Symbol
    Cpne1provided by MGI
    Official Full Name
    copine Iprovided by MGI
    Primary source
    MGI:MGI:2386621
    See related
    Ensembl:ENSMUSG00000074643 Vega:OTTMUSG00000019746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4108; 1810028N16Rik
    Summary
    This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thymus adult (RPKM 29.7), limb E14.5 (RPKM 24.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cpne1 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (156071841..156111965, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (155897577..155937701, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39970 Neighboring gene sperm associated antigen 4 Neighboring gene RNA binding motif protein 12 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0765, KIAA4108

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170588.3NP_733467.1  copine-1

      See identical proteins and their annotated locations for NP_733467.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA154646, AK028882, AK152323, BB873018, BC057554
      Consensus CDS
      CCDS16960.1
      UniProtKB/Swiss-Prot
      Q8C166
      UniProtKB/TrEMBL
      Q3U893
      Related
      ENSMUSP00000105237.2, OTTMUSP00000017195, ENSMUST00000109608.8, OTTMUST00000038382
      Conserved Domains (3) summary
      cd04047
      Location:137244
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:6123
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:250507
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
    2. NM_170590.3NP_733469.1  copine-1

      See identical proteins and their annotated locations for NP_733469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA154646, AK028882, BB873018, BC057554
      Consensus CDS
      CCDS16960.1
      UniProtKB/Swiss-Prot
      Q8C166
      Related
      ENSMUSP00000105236.2, OTTMUSP00000017203, ENSMUST00000109607.9, OTTMUST00000038403
      Conserved Domains (3) summary
      cd04047
      Location:137244
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:6123
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:250507
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      156071841..156111965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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