Format

Send to:

Choose Destination
    • Showing Current items.

    Grk6 G protein-coupled receptor kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 26385, updated on 18-Sep-2018

    Summary

    Official Symbol
    Grk6provided by MGI
    Official Full Name
    G protein-coupled receptor kinase 6provided by MGI
    Primary source
    MGI:MGI:1347078
    See related
    Ensembl:ENSMUSG00000074886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gprk6
    Expression
    Ubiquitous expression in spleen adult (RPKM 77.5), thymus adult (RPKM 59.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Grk6 in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55445072..55460927)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55546695..55562288)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII (Hageman factor) Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic) Neighboring gene drebrin 1 Neighboring gene microRNA 6944

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    beta-adrenergic receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 6
    Names
    g protein-coupled receptor kinase GRK6
    NP_001033107.1
    NP_001106182.1
    NP_001272992.1
    NP_001272993.1
    NP_001272994.1
    NP_001272995.1
    NP_036068.2
    XP_006517314.1
    XP_006517315.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038018.4NP_001033107.1  G protein-coupled receptor kinase 6 isoform a

      See identical proteins and their annotated locations for NP_001033107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      Consensus CDS
      CCDS49272.1
      UniProtKB/Swiss-Prot
      O70293
      Related
      ENSMUSP00000001115.8, ENSMUST00000001115.15
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001112711.2NP_001106182.1  G protein-coupled receptor kinase 6 isoform c

      See identical proteins and their annotated locations for NP_001106182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      UniProtKB/Swiss-Prot
      O70293
      Related
      ENSMUSP00000152968.1, ENSMUST00000224118.1
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001286063.1NP_001272992.1  G protein-coupled receptor kinase 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, Y15799
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      A0A286YDZ5
      Related
      ENSMUSP00000153623.1, ENSMUST00000224653.1
      Conserved Domains (3) summary
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:153437
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:3147
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. NM_001286064.1NP_001272993.1  G protein-coupled receptor kinase 6 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      A0A286YDA5
      Related
      ENSMUSP00000153344.1, ENSMUST00000224995.1
      Conserved Domains (3) summary
      smart00220
      Location:186443
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185464
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    5. NM_001286065.1NP_001272994.1  G protein-coupled receptor kinase 6 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK051405, AW048460, CT009762, Y15799
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      A0A286YE10
      Related
      ENSMUSP00000153668.1, ENSMUST00000225925.1
      Conserved Domains (3) summary
      smart00220
      Location:186414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185435
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001286066.1NP_001272995.1  G protein-coupled receptor kinase 6 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, 3' UTR, and 3' coding region, and cause translation initiation from a downstream start codon. The encoded isoform (g) has a shorter N-terminus and a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      CA528447, CD354984, CT009762, Y15797
      UniProtKB/TrEMBL
      Q9EP84
      Conserved Domains (2) summary
      smart00220
      Location:1183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain
    7. NM_011938.4NP_036068.2  G protein-coupled receptor kinase 6 isoform b

      See identical proteins and their annotated locations for NP_036068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      CA528447, CD354984, CT009762, Y15797
      Consensus CDS
      CCDS36676.1
      UniProtKB/Swiss-Prot
      O70293
      UniProtKB/TrEMBL
      Q9EP84
      Related
      ENSMUSP00000097081.3, ENSMUST00000099482.4
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55445072..55460927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517251.3XP_006517314.1  G protein-coupled receptor kinase 6 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:181443
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:180464
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:30174
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. XM_006517252.1XP_006517315.1  G protein-coupled receptor kinase 6 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:1183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain
    Support Center