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    PLA2G2D phospholipase A2 group IID [ Homo sapiens (human) ]

    Gene ID: 26279, updated on 2-Oct-2018

    Summary

    Official Symbol
    PLA2G2Dprovided by HGNC
    Official Full Name
    phospholipase A2 group IIDprovided by HGNC
    Primary source
    HGNC:HGNC:9033
    See related
    Ensembl:ENSG00000117215 MIM:605630; Vega:OTTHUMG00000002701
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPLASH; sPLA2S; PLA2IID; sPLA2-IID
    Summary
    This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
    Expression
    Biased expression in lymph node (RPKM 63.3), appendix (RPKM 10.7) and 2 other tissues See more
    Orthologs

    Genomic context

    See PLA2G2D in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (20112650..20119566, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20439143..20446059, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IIA Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2 group V Neighboring gene phospholipase A2 group IIF Neighboring gene phospholipase A2 group IIC

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heparan sulfate proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipase A2 activity TAS
    Traceable Author Statement
    more info
     
    phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylcholine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylglycerol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phosphatidylserine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
     
    phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    group IID secretory phospholipase A2
    Names
    GIID sPLA2
    phosphatidylcholine 2-acylhydrolase 2D
    secretory phospholipase A2s
    secretory-type PLA, stroma-associated homolog
    NP_001258743.1
    NP_036532.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271814.1NP_001258743.1  group IID secretory phospholipase A2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK026347, AK310156, BC025706, DC295429
      Consensus CDS
      CCDS72721.1
      UniProtKB/Swiss-Prot
      Q9UNK4
      UniProtKB/TrEMBL
      A0A087WZT4
      Related
      ENSP00000482871.1, ENST00000617227.1
      Conserved Domains (1) summary
      cl05417
      Location:2162
      PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    2. NM_012400.3NP_036532.1  group IID secretory phospholipase A2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_036532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK026347, BC025706, DC295429
      Consensus CDS
      CCDS203.1
      UniProtKB/Swiss-Prot
      Q9UNK4
      Related
      ENSP00000364246.3, OTTHUMP00000002788, ENST00000375105.7, OTTHUMT00000007683
      Conserved Domains (1) summary
      cd00125
      Location:21138
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      20112650..20119566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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