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    FBXL5 F-box and leucine rich repeat protein 5 [ Homo sapiens (human) ]

    Gene ID: 26234, updated on 8-Jul-2021

    Summary

    Official Symbol
    FBXL5provided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 5provided by HGNC
    Primary source
    HGNC:HGNC:13602
    See related
    Ensembl:ENSG00000118564 MIM:605655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBL4; FBL5; FLR1
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in kidney (RPKM 49.5), fat (RPKM 39.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FBXL5 in Genome Data Viewer
    Location:
    4p15.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (15604381..15681544, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15606004..15656980, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986185 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene family with sequence similarity 200 member B Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene prefoldin subunit 1 pseudogene Neighboring gene ribosomal protein L10a pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 5
    Names
    F-box protein FBL4/FBL5
    p45SKP2-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047143.1 RefSeqGene

      Range
      9561..60537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193534.2NP_001180463.1  F-box/LRR-repeat protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001180463.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC116651, AF142481, AF199420, AI858616, BC030656, BF432189
      UniProtKB/Swiss-Prot
      Q9UKA1
      Conserved Domains (4) summary
      cd09293
      Location:353407
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:331356
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:204248
      F-box-like; F-box-like
    2. NM_001193535.2NP_001180464.1  F-box/LRR-repeat protein 5 isoform 4

      See identical proteins and their annotated locations for NP_001180464.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC116651, AI858616, BF432189, BX537957
      Consensus CDS
      CCDS54745.1
      UniProtKB/Swiss-Prot
      Q9UKA1
      Related
      ENSP00000408679.2, ENST00000412094.6
      Conserved Domains (4) summary
      cd09293
      Location:337391
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7143
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:315340
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:188232
      F-box-like; F-box-like
    3. NM_012161.4NP_036293.1  F-box/LRR-repeat protein 5 isoform 1

      See identical proteins and their annotated locations for NP_036293.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC116651, AF142481, AI858616, BC030656, BF432189
      Consensus CDS
      CCDS3415.1
      UniProtKB/Swiss-Prot
      Q9UKA1
      Related
      ENSP00000344866.3, ENST00000341285.8
      Conserved Domains (4) summary
      cd09293
      Location:354408
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:332357
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:205249
      F-box-like; F-box-like

    RNA

    1. NR_036464.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC116651, AI858616, BC012320, BC030656, BF432189
      Related
      ENST00000511441.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      15604381..15681544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008019.2XP_016863508.1  F-box/LRR-repeat protein 5 isoform X3

      Conserved Domains (4) summary
      cd09293
      Location:299353
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:1105
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:277302
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:150194
      F-box-like; F-box-like
    2. XM_006713959.3XP_006714022.1  F-box/LRR-repeat protein 5 isoform X1

      Conserved Domains (4) summary
      cd09293
      Location:335389
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:10141
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:313338
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:186230
      F-box-like; F-box-like
    3. XM_011513832.2XP_011512134.1  F-box/LRR-repeat protein 5 isoform X3

      Related
      ENSP00000425472.1, ENST00000513163.5
      Conserved Domains (4) summary
      cd09293
      Location:299353
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:1105
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:277302
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:150194
      F-box-like; F-box-like
    4. XM_011513831.2XP_011512133.1  F-box/LRR-repeat protein 5 isoform X2

      Conserved Domains (4) summary
      cd09293
      Location:318372
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:9124
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:296321
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:169213
      F-box-like; F-box-like
    5. XM_011513833.2XP_011512135.1  F-box/LRR-repeat protein 5 isoform X4

      Conserved Domains (4) summary
      cd09293
      Location:282336
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:260285
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:133177
      F-box-like; F-box-like
      cl15774
      Location:2088
      Hemerythrin-like; Hemerythrin family
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