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    TAS2R40 taste 2 receptor member 40 [ Homo sapiens (human) ]

    Gene ID: 259286, updated on 23-May-2018


    Official Symbol
    TAS2R40provided by HGNC
    Official Full Name
    taste 2 receptor member 40provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000221937 MIM:613964; Vega:OTTHUMG00000152638
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR60; T2R40; T2R58
    This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]

    Genomic context

    See TAS2R40 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (143222037..143223079)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142919172..142920143)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene prolactin induced protein Neighboring gene taste 2 receptor member 39 Neighboring gene uncharacterized LOC105375546 Neighboring gene uncharacterized LOC105375545 Neighboring gene glutathione S-transferase kappa 1

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of taste receptor, type 2, member 40 (TAS2R40) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
      Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...

    General gene information



    Clone Names

    • MGC126844, MGC126846

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    bitter taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    Component Evidence Code Pubs
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    integral component of membrane IC
    Inferred by Curator
    more info
    plasma membrane TAS
    Traceable Author Statement
    more info

    General protein information

    Preferred Names
    taste receptor type 2 member 40
    G-protein coupled receptor 60
    taste receptor type 2 member 58
    taste receptor, type 2, member 40

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176882.2NP_795363.1  taste receptor type 2 member 40

      See identical proteins and their annotated locations for NP_795363.1

      Status: REVIEWED

      Source sequence(s)
      Consensus CDS
      ENSP00000386210.3, OTTHUMP00000202106, ENST00000408947.4
      Conserved Domains (1) summary
      7tm_TAS2R40; mammalian taste receptor 2, subtype 40, member of the seven-transmembraneG-protein coupled receptor superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly


    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)
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