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    Ccne1 cyclin E1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25729, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ccne1provided by RGD
    Official Full Name
    cyclin E1provided by RGD
    Primary source
    RGD:2294
    See related
    Ensembl:ENSRNOG00000014786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccne; CYCLE
    Summary
    a cyclin-like protein; may be involved in growth stimulation [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 120.2), Thymus (RPKM 85.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ccne1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (94485830..94495112, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (95575136..95584387, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene URI1, prefoldin-like chaperone Neighboring gene uncharacterized LOC108349566 Neighboring gene similar to mitochondrial ribosomal protein L32 Neighboring gene similar to CG3740-PA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein serine/threonine kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    antral ovarian follicle growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chromosome organization involved in meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to methylmercury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to purine-containing compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synapsis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapsis IEA
    Inferred from Electronic Annotation
    more info
     
    synapsis ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin E1-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin E1-CDK2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin E1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G1/S-specific cyclin-E1
    Names
    cyclin E

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100821.1NP_001094291.1  G1/S-specific cyclin-E1

      See identical proteins and their annotated locations for NP_001094291.1

      Status: VALIDATED

      Source sequence(s)
      BU760054, CK842479, DY561075, EV771022
      UniProtKB/TrEMBL
      B1WC54
      Conserved Domains (2) summary
      pfam00134
      Location:116243
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:246365
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      94485830..94495112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228904.3XP_006228966.1  G1/S-specific cyclin-E1 isoform X1

      See identical proteins and their annotated locations for XP_006228966.1

      UniProtKB/TrEMBL
      B1WC54
      Related
      ENSRNOP00000020014.4, ENSRNOT00000020014.4
      Conserved Domains (2) summary
      pfam00134
      Location:116243
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:246365
      Cyclin_C; Cyclin, C-terminal domain

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      85114968..85124206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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