Format

Send to:

Choose Destination
    • Showing Current items.

    Smad3 SMAD family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25631, updated on 2-Oct-2018

    Summary

    Official Symbol
    Smad3provided by RGD
    Official Full Name
    SMAD family member 3provided by RGD
    Primary source
    RGD:3032
    See related
    Ensembl:ENSRNOG00000008620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mad3; Madh3; Smad 3
    Summary
    transcription factor; important component of the TGF-beta signaling pathway [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 301.2), Kidney (RPKM 125.7) and 9 other tissues See more
    Orthologs

    Genomic context

    See Smad3 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (68569530..68678349, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (68290927..68397727, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693117 Neighboring gene IQ motif containing H Neighboring gene alpha- and gamma-adaptin binding protein Neighboring gene SMAD family member 6 Neighboring gene zwilch kinetochore protein Neighboring gene lactase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Activin signaling, organism-specific biosystem (from KEGG)
      Activin signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Activin signaling, conserved biosystem (from KEGG)
      Activin signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem
      Alpha6-Beta4 Integrin Signaling Pathway
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystem (from REACTOME)
      Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Downregulation of TGF-beta receptor signaling, organism-specific biosystem (from REACTOME)
      Downregulation of TGF-beta receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, organism-specific biosystem (from REACTOME)
      SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Activin, organism-specific biosystem (from REACTOME)
      Signaling by Activin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by NODAL, organism-specific biosystem (from REACTOME)
      Signaling by NODAL, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
      Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
      TGF-beta receptor signaling activates SMADs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TGF-beta signaling, organism-specific biosystem (from KEGG)
      TGF-beta signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • TGF-beta signaling, conserved biosystem (from KEGG)
      TGF-beta signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
      Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DEAD/H-box RNA helicase binding IEA
    Inferred from Electronic Annotation
    more info
     
    DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    bHLH transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    co-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mineralocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    mineralocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    primary miRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SMAD protein complex assembly IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adrenal gland development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic cranial skeleton morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic cranial skeleton morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic foregut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    evasion or tolerance of host defenses by virus IEA
    Inferred from Electronic Annotation
    more info
     
    evasion or tolerance of host defenses by virus ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    immune system development IEA
    Inferred from Electronic Annotation
    more info
     
    immune system development ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    lens fiber cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lens fiber cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    liver development ISO
    Inferred from Sequence Orthology
    more info
     
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    mesoderm formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cardiac muscle hypertrophy in response to stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lung blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    nodal signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast development ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    paraxial mesoderm morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    paraxial mesoderm morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pericardium development IEA
    Inferred from Electronic Annotation
    more info
     
    pericardium development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of alkaline phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of bone mineralization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular matrix assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta3 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of striated muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transforming growth factor beta2 production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta2 production ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
     
    transdifferentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SMAD protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    heteromeric SMAD protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 3
    Names
    MAD (mothers against decapentaplegic, Drosophila) homolog 3
    MAD homolog 3
    mothers against DPP homolog 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013095.3NP_037227.1  mothers against decapentaplegic homolog 3

      See identical proteins and their annotated locations for NP_037227.1

      Status: VALIDATED

      Source sequence(s)
      AABR07070393, BC064437
      UniProtKB/Swiss-Prot
      P84025
      Related
      ENSRNOP00000037346.3, ENSRNOT00000039730.4
      Conserved Domains (2) summary
      cd10491
      Location:8132
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:224414
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      68569530..68678349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766216.2XP_008764438.1  mothers against decapentaplegic homolog 3 isoform X1

      See identical proteins and their annotated locations for XP_008764438.1

      Conserved Domains (1) summary
      cd10985
      Location:29219
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      63537497..63647062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center