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    Lep leptin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25608, updated on 14-Oct-2018

    Summary

    Official Symbol
    Lepprovided by RGD
    Official Full Name
    leptinprovided by RGD
    Primary source
    RGD:3000
    See related
    Ensembl:ENSRNOG00000045797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OB; obese
    Summary
    involved in regulation of body weight, and may have a role in angiogenesis [RGD, Feb 2006]
    Expression
    Biased expression in Adrenal (RPKM 108.2), Thymus (RPKM 61.6) and 5 other tissues See more
    Orthologs

    Genomic context

    See Lep in Genome Data Viewer
    Location:
    4q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56337695..56351818)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (56085079..56099209)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene microRNA 129-1 Neighboring gene uncharacterized LOC108350681 Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of protein kinase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    adult feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    adult feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    bile acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    bone growth ISO
    Inferred from Sequence Orthology
    more info
     
    bone growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bone mineralization involved in bone maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to leptin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    energy reserve metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-6 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-8 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte tethering or rolling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of appetite by leptin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of appetite by leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glucagon secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glutamine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vasoconstriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ovulation from ovarian follicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of JAK-STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cytokine production IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of follicle-stimulating hormone secretion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of hepatic stellate cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of luteinizing hormone secretion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bone remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intestinal cholesterol absorption IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intestinal cholesterol absorption ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipoprotein lipid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of natural killer cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of natural killer cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of natural killer cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nitric-oxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sexual reproduction ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leptin
    Names
    obesity factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013076.3NP_037208.1  leptin precursor

      See identical proteins and their annotated locations for NP_037208.1

      Status: VALIDATED

      Source sequence(s)
      AC096035
      UniProtKB/Swiss-Prot
      P50596
      Related
      ENSRNOP00000066184.1, ENSRNOT00000071926.1
      Conserved Domains (1) summary
      pfam02024
      Location:26167
      Leptin; Leptin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      56337695..56351818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762762.2XP_008760984.1  leptin isoform X1

      See identical proteins and their annotated locations for XP_008760984.1

      UniProtKB/Swiss-Prot
      P50596
      Conserved Domains (1) summary
      pfam02024
      Location:26167
      Leptin; Leptin

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      52770132..52784148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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