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    SLC41A1 solute carrier family 41 member 1 [ Homo sapiens (human) ]

    Gene ID: 254428, updated on 8-Jul-2018
    Official Symbol
    SLC41A1provided by HGNC
    Official Full Name
    solute carrier family 41 member 1provided by HGNC
    Primary source
    HGNC:HGNC:19429
    See related
    Ensembl:ENSG00000133065 MIM:610801; Vega:OTTHUMG00000036000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MgtE
    Expression
    Broad expression in heart (RPKM 55.1), testis (RPKM 27.0) and 20 other tissues See more
    Orthologs
    See SLC41A1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (205789093..205813759, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205758221..205782887, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371702 Neighboring gene RAB29, member RAS oncogene family Neighboring gene peptidase M20 domain containing 1 Neighboring gene uncharacterized LOC107985250 Neighboring gene uncharacterized LOC284581

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
    NHGRI GWA Catalog
    Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
    NHGRI GWA Catalog
    Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
    NHGRI GWA Catalog
    Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
    NHGRI GWA Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    divalent inorganic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    magnesium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to magnesium ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    divalent metal ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    magnesium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    solute carrier family 41 member 1
    Names
    solute carrier family 41 (magnesium transporter), member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173854.5NP_776253.3  solute carrier family 41 member 1

      See identical proteins and their annotated locations for NP_776253.3

      Status: VALIDATED

      Source sequence(s)
      BC136303, BX641054, BX648979, DA496198, HY148928
      Consensus CDS
      CCDS30988.1
      UniProtKB/Swiss-Prot
      Q8IVJ1
      UniProtKB/TrEMBL
      B2RMP2
      Related
      ENSP00000356105.3, OTTHUMP00000034231, ENST00000367137.3, OTTHUMT00000087731
      Conserved Domains (1) summary
      pfam01769
      Location:139270
      MgtE; Divalent cation transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      205789093..205813759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245069.2XP_005245126.1  solute carrier family 41 member 1 isoform X1

      See identical proteins and their annotated locations for XP_005245126.1

      UniProtKB/Swiss-Prot
      Q8IVJ1
      UniProtKB/TrEMBL
      B2RMP2
      Conserved Domains (1) summary
      pfam01769
      Location:139270
      MgtE; Divalent cation transporter
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