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    Gdf5 growth differentiation factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252835, updated on 21-Jul-2018

    Summary

    Official Symbol
    Gdf5provided by RGD
    Official Full Name
    growth differentiation factor 5provided by RGD
    Primary source
    RGD:620102
    See related
    Ensembl:ENSRNOG00000050123
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdmp1
    Summary
    member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily; regulates cell growth and differentiation; involved with tendon and ligament formation [RGD, Feb 2006]
    Expression
    Biased expression in Uterus (RPKM 14.8), Adrenal (RPKM 5.0) and 7 other tissues See more
    Orthologs

    Genomic context

    See Gdf5 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151482672..151487129, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (157849749..157853231, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83, member C Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 1 Neighboring gene centrosomal protein 250 Neighboring gene uncharacterized LOC102550306

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    BMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    BMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chondroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    chondroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mesenchymal cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mesenchymal cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ossification involved in bone remodeling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transmembrane receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    growth differentiation factor 5; growth/differentiation factor 5
    Names
    cartilage-derived morphogenetic protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      151482672..151487129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003749600.4XP_003749648.1  growth/differentiation factor 5

      See identical proteins and their annotated locations for XP_003749648.1

      UniProtKB/TrEMBL
      M0RAY4
      Related
      ENSRNOP00000066703.1, ENSRNOT00000073736.3
      Conserved Domains (2) summary
      smart00204
      Location:394495
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:139338
      TGFb_propeptide; TGF-beta propeptide

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      143176803..143181254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001066344.6XP_001066344.1  growth/differentiation factor 5

      See identical proteins and their annotated locations for XP_001066344.1

      UniProtKB/TrEMBL
      M0RAY4
      Conserved Domains (2) summary
      smart00204
      Location:394495
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:139338
      TGFb_propeptide; TGF-beta propeptide
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