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    Th tyrosine hydroxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25085, updated on 30-Apr-2019

    Summary

    Official Symbol
    Thprovided by RGD
    Official Full Name
    tyrosine hydroxylaseprovided by RGD
    Primary source
    RGD:3853
    See related
    Ensembl:ENSRNOG00000020410
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    The
    Summary
    catalyzes the rate limiting step in catecholamine biosynthesis; may be involved in response to hypoxia [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 273.3) See more
    Orthologs

    Genomic context

    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216073034..216080287, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (222935462..222942715, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549619 Neighboring gene uncharacterized LOC108349673 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    amino acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    amino acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    dopamine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ferric iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxygen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tetrahydrobiopterin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tyrosine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tyrosine 3-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    aminergic neurotransmitter loading into synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    catecholamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to manganese ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian sleep/wake cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cognition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine biosynthetic process from tyrosine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epinephrine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    epinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    eye photoreceptor cell development IEA
    Inferred from Electronic Annotation
    more info
     
    eye photoreceptor cell development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    fatty acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glycoside metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    isoquinoline alkaloid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    learning ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    mating behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neurotransmitter biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    phthalate metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    phytoalexin metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    protein homotetramerization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to ether IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to herbicide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insecticide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to isolation stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to pyrethroid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to salt stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of sound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    social behavior IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sphingolipid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    terpene metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    visual perception ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine 3-monooxygenase
    Names
    tyrosine 3-hydroxylase
    NP_036872.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012740.3NP_036872.1  tyrosine 3-monooxygenase

      See identical proteins and their annotated locations for NP_036872.1

      Status: PROVISIONAL

      Source sequence(s)
      M10244
      UniProtKB/Swiss-Prot
      P04177
      Related
      ENSRNOP00000027682.3, ENSRNOT00000027682.5
      Conserved Domains (4) summary
      TIGR01269
      Location:38495
      Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
      cd04930
      Location:38158
      ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
      pfam00351
      Location:165495
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      pfam12549
      Location:226
      TOH_N; Tyrosine hydroxylase N terminal

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      216073034..216080287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      195642057..195649203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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