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    ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens (human) ]

    Gene ID: 247, updated on 3-Jun-2018
    Official Symbol
    ALOX15Bprovided by HGNC
    Official Full Name
    arachidonate 15-lipoxygenase, type Bprovided by HGNC
    Primary source
    HGNC:HGNC:434
    See related
    Ensembl:ENSG00000179593 MIM:603697; Vega:OTTHUMG00000108181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    15-LOX-2
    Summary
    This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 42.3), esophagus (RPKM 13.5) and 2 other tissues See more
    Orthologs
    See ALOX15B in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (8039040..8049134)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7942343..7952452)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371517 Neighboring gene guanylate cyclase 2D, retinal Neighboring gene arachidonate lipoxygenase 3 pseudogene 1 Neighboring gene uncharacterized LOC107985075 Neighboring gene arachidonate 12-lipoxygenase, 12R type

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonate 15-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonate 15-lipoxygenase activity TAS
    Traceable Author Statement
    more info
     
    arachidonate 8(S)-lipoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    linoleate 13S-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hepoxilin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    lipoxygenase pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage derived foam cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    prostate gland development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of epithelial cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    arachidonate 15-lipoxygenase B
    Names
    15-LOX-B
    15S-lipoxygenase
    arachidonate 15-lipoxygenase 2
    arachidonate 15-lipoxygenase type II
    arachidonate 15-lipoxygenase, second type
    arachidonate omega(6) lipoxygenase
    linoleate 13-lipoxygenase 15-LOb
    NP_001034219.1
    NP_001034220.1
    NP_001132.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029482.1 RefSeqGene

      Range
      5001..15095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039130.1NP_001034219.1  arachidonate 15-lipoxygenase B isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant d. The encoded isoform (a) is shorter than isoform d.
      Source sequence(s)
      AF468052, BC063647, BP327830, CA307212, CA405703
      Consensus CDS
      CCDS32558.1
      UniProtKB/Swiss-Prot
      O15296
      Related
      ENSP00000369520.2, ENST00000380173.6
      Conserved Domains (2) summary
      cd01753
      Location:2121
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:232638
      Lipoxygenase; Lipoxygenase
    2. NM_001039131.1NP_001034220.1  arachidonate 15-lipoxygenase B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) has multiple differences in the coding region but maintains the reading frame, compared to variant d. The encoded isoform (b) is shorter than isoform d.
      Source sequence(s)
      AF468053, BC063647, BP327830, CA307212, CA405703
      Consensus CDS
      CCDS32559.1
      UniProtKB/Swiss-Prot
      O15296
      Related
      ENSP00000460332.2, OTTHUMP00000258940, ENST00000573359.1, OTTHUMT00000441175
      Conserved Domains (2) summary
      cd01753
      Location:2121
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:232593
      Lipoxygenase; Lipoxygenase
    3. NM_001141.2NP_001132.2  arachidonate 15-lipoxygenase B isoform d

      See identical proteins and their annotated locations for NP_001132.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AF468051, BC063647, BP327830, CA307212, CA405703
      Consensus CDS
      CCDS11128.1
      UniProtKB/Swiss-Prot
      O15296
      Related
      ENSP00000369530.4, OTTHUMP00000135321, ENST00000380183.8, OTTHUMT00000226985
      Conserved Domains (2) summary
      cd01753
      Location:2121
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:232667
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      8039040..8049134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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