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    Ppbp pro-platelet basic protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246358, updated on 18-Apr-2019

    Summary

    Official Symbol
    Ppbpprovided by RGD
    Official Full Name
    pro-platelet basic proteinprovided by RGD
    Primary source
    RGD:70548
    See related
    Ensembl:ENSRNOG00000002829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cxcl7; Nap-2
    Summary
    has 72.6% amino acid sequence identity with the mouse homolog which displays increased expression in response to thrombopoietin stimulation [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 335.0) See more

    Genomic context

    See Ppbp in Genome Data Viewer
    Location:
    14p22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18852433..18853237, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (18762075..18762879, complement)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549742 Neighboring gene uncharacterized LOC108352723 Neighboring gene platelet factor 4 Neighboring gene uncharacterized LOC103692658 Neighboring gene C-X-C motif chemokine ligand 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    PubMed 
    platelet formation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    platelet basic protein
    Names
    chemokine (C-X-C motif) ligand 7
    neutrophil activating peptide-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153721.1NP_714943.1  platelet basic protein precursor

      See identical proteins and their annotated locations for NP_714943.1

      Status: PROVISIONAL

      Source sequence(s)
      AF349115
      UniProtKB/TrEMBL
      Q99ME0
      Related
      ENSRNOP00000003794.1, ENSRNOT00000003794.3
      Conserved Domains (1) summary
      cd00273
      Location:47109
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      18852433..18853237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      16678302..16679106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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