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    Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246211, updated on 21-Jul-2018

    Summary

    Official Symbol
    Hsd3b7provided by RGD
    Official Full Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by RGD
    Primary source
    RGD:628727
    See related
    Ensembl:ENSRNOG00000019080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cca2
    Summary
    protein that is expressed in under growth-arrest conditions [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 642.2), Adrenal (RPKM 146.1) and 8 other tissues See more
    Orthologs

    Genomic context

    See Hsd3b7 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199248084..199251745)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (206270509..206274641)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC108349648

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    B cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    B cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    B cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bile acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cholesterol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cholesterol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    3 beta-hydroxysteroid dehydrogenase type 7
    Names
    3 beta-hydroxysteroid dehydrogenase type VII
    3-beta-HSD VII
    3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
    c(27) 3-beta-HSD
    cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
    confluent 3Y1 cell-associated 2
    NP_647545.1
    XP_006230274.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139329.1NP_647545.1  3 beta-hydroxysteroid dehydrogenase type 7

      See identical proteins and their annotated locations for NP_647545.1

      Status: PROVISIONAL

      Source sequence(s)
      AB000199
      UniProtKB/Swiss-Prot
      O35048
      Related
      ENSRNOP00000025933.4, ENSRNOT00000025933.4
      Conserved Domains (2) summary
      pfam01073
      Location:13252
      3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
      cl21454
      Location:11330
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      199248084..199251745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230212.3XP_006230274.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform X1

      See identical proteins and their annotated locations for XP_006230274.1

      Conserved Domains (2) summary
      pfam01073
      Location:13283
      3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
      cl21454
      Location:11361
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      180063215..180066485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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