Format

Send to:

Choose Destination
    • Showing Current items.

    Nppa natriuretic peptide A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24602, updated on 12-Aug-2018

    Summary

    Official Symbol
    Nppaprovided by RGD
    Official Full Name
    natriuretic peptide Aprovided by RGD
    Primary source
    RGD:3193
    See related
    Ensembl:ENSRNOG00000008176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ANF; ANP; Pnd; RATANF
    Summary
    peptide involved in the control of fluid volume and vascular function [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 15587.0) See more
    Orthologs

    Genomic context

    See Nppa in Genome Data Viewer
    Location:
    5q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164808407..164809716)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (168466309..168467618)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 2510039O18 Neighboring gene natriuretic peptide B Neighboring gene chloride voltage-gated channel 6 Neighboring gene methylenetetrahydrofolate reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    cell growth involved in cardiac muscle cell development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    female pregnancy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organismal water homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of collecting lymphatic vessel constriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of systemic arterial blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histamine secretion by mast cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor guanylyl cyclase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    receptor guanylyl cyclase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of atrial cardiac muscle cell membrane repolarization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of atrial cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of blood vessel size IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of body fluid levels TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of high voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    natriuretic peptides A
    Names
    Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd)
    atrial natriuretic factor
    atrial natriuretic peptide
    natriuretic peptide precursor type A
    prepronatriodilatin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012612.2NP_036744.1  natriuretic peptides A precursor

      See identical proteins and their annotated locations for NP_036744.1

      Status: VALIDATED

      Source sequence(s)
      AI602287, CB724799, X00665
      UniProtKB/Swiss-Prot
      P01161
      UniProtKB/TrEMBL
      B0BMW5
      Related
      ENSRNOP00000011005.3, ENSRNOT00000011005.5
      Conserved Domains (1) summary
      smart00183
      Location:122145
      NAT_PEP; Natriuretic peptide

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      164808407..164809716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      156710885..156712194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center