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    Gstm2 glutathione S-transferase mu 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24424, updated on 5-Aug-2018

    Summary

    Official Symbol
    Gstm2provided by RGD
    Official Full Name
    glutathione S-transferase mu 2provided by RGD
    Primary source
    RGD:2756
    See related
    Ensembl:ENSRNOG00000018937
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSTA4
    Summary
    subunit of glutathione S-transferase, which may play a role in xenobiotic metabolism and response to oxidative stress [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 2814.2), Testes (RPKM 1345.5) and 5 other tissues See more

    Genomic context

    See Gstm2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210778041..210782807, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (230247260..230251618, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550192 Neighboring gene glutathione S-transferase mu 3-like Neighboring gene glutathione S-transferase mu 1 Neighboring gene glutathione S-transferase mu 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular detoxification of nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
     
    cellular detoxification of nitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    nitrobenzene metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nitrobenzene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    response to catechin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to genistein IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase Mu 2
    Names
    GST 4-4
    GST Yb2
    GSTM2-2
    Glutathione-S-transferase, mu type 2 (Yb2)
    glutathione S-transferase M2
    glutathione S-transferase Yb-2
    glutathione S-transferase Yb2 subunit
    NP_803175.1
    XP_017446116.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177426.1NP_803175.1  glutathione S-transferase Mu 2

      See identical proteins and their annotated locations for NP_803175.1

      Status: PROVISIONAL

      Source sequence(s)
      J03914
      UniProtKB/Swiss-Prot
      P08010
      UniProtKB/TrEMBL
      B6DYQ2
      Related
      ENSRNOP00000025939.1, ENSRNOT00000025939.4
      Conserved Domains (3) summary
      PTZ00057
      Location:3200
      PTZ00057; glutathione s-transferase; Provisional
      cd03209
      Location:92212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:384
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      210778041..210782807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590627.1XP_017446116.1  glutathione S-transferase Mu 2 isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      188270799..188275157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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