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    Gstm1 glutathione S-transferase mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24423, updated on 5-Aug-2018

    Summary

    Official Symbol
    Gstm1provided by RGD
    Official Full Name
    glutathione S-transferase mu 1provided by RGD
    Primary source
    RGD:2755
    See related
    Ensembl:ENSRNOG00000029726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GSTA3
    Summary
    multifunctional enzyme thought to have scavenger function; able to neutralize harmful metabolites from foreign substances [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 1582.2), Testes (RPKM 556.6) and 7 other tissues See more

    Genomic context

    See Gstm1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210803869..210809461, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (230272740..230278278, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 3-like Neighboring gene glutathione S-transferase mu 2 Neighboring gene glutathione S-transferase mu 4 Neighboring gene adenosine monophosphate deaminase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nickel cation binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular detoxification of nitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nitrobenzene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutathione S-transferase Mu 1
    Names
    GST 3-3
    GST Yb1
    GSTM1-1
    glutathione S-transferase M1
    glutathione S-transferase Yb-1 subunit
    glutathione-S-transferase, mu type 1 (Yb1)
    NP_058710.1
    XP_017446115.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017014.1NP_058710.1  glutathione S-transferase Mu 1

      See identical proteins and their annotated locations for NP_058710.1

      Status: PROVISIONAL

      Source sequence(s)
      J02810
      UniProtKB/Swiss-Prot
      P04905
      Related
      ENSRNOP00000039050.2, ENSRNOT00000047139.3
      Conserved Domains (3) summary
      PTZ00057
      Location:3203
      PTZ00057; glutathione s-transferase; Provisional
      cd03209
      Location:92211
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:384
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      210803869..210809461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590626.1XP_017446115.1  glutathione S-transferase Mu 1 isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      188295244..188300621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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