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    Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24307, updated on 21-Jul-2018

    Summary

    Official Symbol
    Cyp4b1provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily b, polypeptide 1provided by RGD
    Primary source
    RGD:2480
    See related
    Ensembl:ENSRNOG00000055078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may activate carcinogenic amines and contribute to bladder cancer [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 940.3), Kidney (RPKM 160.3) and 4 other tissues See more
    Orthologs

    Genomic context

    See Cyp4b1 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134508728..134526103, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (138299551..138316860, complement)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 3 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 1 Neighboring gene similar to farnesyl diphosphate synthetase Neighboring gene EF-hand calcium binding domain 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fluorene oxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    toxic substance binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    biphenyl metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular aromatic compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular aromatic compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exogenous drug catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exogenous drug catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fluorene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 4B1
    Names
    CYPIVB1
    P450 L-2
    P450-isozyme 5
    cytochrome P450 L-2
    cytochrome P450 isozyme 5
    cytochrome P450, subfamily 4B, polypeptide 1
    cytochrome P450, subfamily IVB, polypeptide 1
    NP_058695.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016999.2NP_058695.2  cytochrome P450 4B1

      See identical proteins and their annotated locations for NP_058695.2

      Status: PROVISIONAL

      Source sequence(s)
      M29853
      UniProtKB/Swiss-Prot
      P15129
      Related
      ENSRNOP00000013321.4, ENSRNOT00000013321.6
      Conserved Domains (1) summary
      pfam00067
      Location:47500
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      134508728..134526103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001837834.1 RNA Sequence

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      127676727..127694036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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