Format

Send to:

Choose Destination
    • Showing Current items.

    C4bpa complement component 4 binding protein, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24235, updated on 21-Jul-2018

    Summary

    Official Symbol
    C4bpaprovided by RGD
    Official Full Name
    complement component 4 binding protein, alphaprovided by RGD
    Primary source
    RGD:2235
    See related
    Ensembl:ENSRNOG00000004062
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C4BP
    Summary
    regulatory protein for the complement system of the innate immune response [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 3725.1) See more
    Orthologs

    Genomic context

    See C4bpa in Genome Data Viewer
    Location:
    13q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47342090..47377580, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (52430754..52466244, complement)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene zona pellucida 3 receptor Neighboring gene Sm protein F-like Neighboring gene complement component 4 binding protein, beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC108761

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    complement binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    single fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    acrosomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    other organism cell ISO
    Inferred from Sequence Orthology
    more info
     
    outer acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    zona pellucida receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C4b-binding protein alpha chain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012516.2NP_036648.2  C4b-binding protein alpha chain

      See identical proteins and their annotated locations for NP_036648.2

      Status: PROVISIONAL

      Source sequence(s)
      BC088165
      UniProtKB/TrEMBL
      Q5M891
      Related
      ENSRNOP00000005461.3, ENSRNOT00000005461.5
      Conserved Domains (4) summary
      cd00033
      Location:182243
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:372429
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:300544
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:490544
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      47342090..47377580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      42426949..42461963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center